Gao M, Zhong A, Patel N, Alur C, Vyas D. High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases. World J Gastroenterol 2017; 23(16): 2819-2825 [PMID: 28522900 DOI: 10.3748/wjg.v23.i16.2819]
Corresponding Author of This Article
Dinesh Vyas, MD, FACS, Associate Dean of Surgery Research, Department of Surgery, Texas Tech University, 701 West 5th Street, Suite 2263 Odessa, TX 79763, United States. dineshvyas@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 28, 2017; 23(16): 2819-2825 Published online Apr 28, 2017. doi: 10.3748/wjg.v23.i16.2819
High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases
Mamie Gao, Allen Zhong, Neil Patel, Chiraag Alur, Dinesh Vyas
Mamie Gao, Allen Zhong, Neil Patel, Chiraag Alur, Dinesh Vyas, Department of Surgery, Texas Tech University, Odessa, TX 79763, United States
Author contributions: Gao M and Zhong A have contributed equally as first co-authors; Gao M, Zhong A and Vyas D were involved with the conception, development of the study, data collection and writing the article; Patel N, Alur C and Vyas D were involved with data analysis and interpretation; Vyas D approved the final version.
Conflict-of-interest statement: The authors have no conflicts of interest or financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dinesh Vyas, MD, FACS, Associate Dean of Surgery Research, Department of Surgery, Texas Tech University, 701 West 5th Street, Suite 2263 Odessa, TX 79763, United States. dineshvyas@yahoo.com
Telephone: +1-432-7035290 Fax: +1-432-3351693
Received: September 15, 2016 Peer-review started: September 19, 2016 First decision: October 28, 2016 Revised: November 16, 2016 Accepted: March 15, 2017 Article in press: March 15, 2017 Published online: April 28, 2017
Abstract
RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes (DEG’s), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), and irritable bowel syndrome.
Core tip: RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), and irritable bowel syndrome.
