Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2016; 22(6): 2046-2059
Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.2046
Glucose metabolism in gastric cancer: The cutting-edge
Lian-Wen Yuan, Hiroharu Yamashita, Yasuyuki Seto
Lian-Wen Yuan, Department of Geriatric Surgery, Second Xiangya Hospital, Center-South University, Changsha 410011, Hunan Province, China
Lian-Wen Yuan, Hiroharu Yamashita, Yasuyuki Seto, Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan
Author contributions: Yuan LW performed the literature search and wrote the review; Yamashita H and Seto Y participated in revising the review.
Supported by The China Scholarship Council, No. [2014]3012.
Conflict-of-interest statement: The authors declare that they have no competing interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Lian-Wen Yuan, MD, PhD, Associate Professor, Visiting Researcher, Department of Geriatrics Surgery, Second Xiangya Hospital, Center-South University, Yuelu District, 932 South Lushan Rd, Changsha 410011, Hunan Province, China.
Telephone: +86-731-85295167 Fax: +86-731-5362966
Received: June 20, 2015
Peer-review started: June 25, 2015
First decision: July 10, 2015
Revised: September 18, 2015
Accepted: November 30, 2015
Article in press: November 30, 2015
Published online: February 14, 2016

Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis (Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.

Keywords: Glucose metabolism, Warburg effect, Metabolomics, Gastric cancer, Biomarker, Therapy

Core tip: Increased glucose consumption is a hallmark of cancer cells. Studies focusing on glucose metabolism provide a new perspective on gastric carcinogenesis and a novel approach to exploration of biomarkers and therapeutic targets in gastric cancer.