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Oshiro Y, Gen R, Hashimoto S, Oda T, Sato T, Ohkohchi N. Neuroendocrine carcinoma of the extrahepatic bile duct: A case report. World J Gastroenterol 2016; 22(30): 6960-6964 [PMID: 27570432 DOI: 10.3748/wjg.v22.i30.6960]
Yukio Oshiro, Ryozo Gen, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Taiki Sato, Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Author contributions: All authors contributed substantially to the acquisition, analysis, and interpretation of the data and participated in writing the paper; Ohkohchi N gave final approval of the version to be published.
Supported byDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Japan.
Institutional review board statement: The University of Tsukuba Hospital Institutional Review Board does not require approval for case reports.
Informed consent statement: The patient involved in this case report authorized the disclosure of his protected health information for academic purposes.
Conflict-of-interest statement: All authors indicate that they have no financial interests or potential conflicts of interest to declare.
Correspondence to: Yukio Oshiro, MD, PhD, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan. oshiro@md.tsukuba.ac.jp
Telephone: +81-29-8533221 Fax: +81-29-8533222
Received: March 28, 2016 Peer-review started: March 31, 2016 First decision: May 12, 2016 Revised: May 24, 2016 Accepted: June 13, 2016 Article in press: June 13, 2016 Published online: August 14, 2016 Processing time: 129 Days and 7.5 Hours
Abstract
Neuroendocrine carcinoma (NEC) originating from the gastrointestinal hepatobiliary-pancreas is a rare, invasive, and progressive disease, for which the prognosis is extremely poor. The patient was a 72-year-old man referred with complaints of jaundice. He was diagnosed with middle extrahepatic cholangiocarcinoma (cT4N1M0, cStage IV). He underwent a right hepatectomy combined with extrahepatic bile duct and portal vein resection after percutaneous transhepatic portal vein embolization. Microscopic examination showed a large-cell neuroendocrine carcinoma according to the WHO criteria for the clinicopathologic classification of gastroenteropancreatic neuroendocrine tumors. Currently, the patient is receiving combination chemotherapy with cisplatin and etoposide for postoperative multiple liver metastases. Although NEC is difficult to diagnose preoperatively, it should be considered an uncommon alternative diagnosis.
Core tip: We encountered a resected case of a neuroendocrine carcinoma originating from the extrahepatic bile duct. Although neuroendocrine carcinoma is rare and difficult to diagnose preoperatively, it should be considered an uncommon alternative diagnosis.
