Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2015; 21(46): 12996-13003
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.12996
Therapeutic role of endoscopic ultrasound in pancreaticobiliary disease: A comprehensive review
Fan-Sheng Meng, Zhao-Hong Zhang, Feng Ji
Fan-Sheng Meng, Feng Ji, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Zhao-Hong Zhang, Department of Hematology, Linyi People’s Hospital, Linyi 276300, Shandong Province, China
Author contributions: Meng FS and Zhang ZH searched the literature and wrote the manuscript; Ji F critically revised the manuscript; Meng FS and Zhang ZH contributed equally to this work.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Feng Ji, MD, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road No.79, Hangzhou 310000, Zhejiang Province, China. jifeng1126@sina.com
Telephone: +86-571-87236586 Fax: +86-571-87236611
Received: March 19, 2015
Peer-review started: March 26, 2015
First decision: July 19, 2015
Revised: August 10, 2015
Accepted: September 28, 2015
Article in press: September 30, 2015
Published online: December 14, 2015
Processing time: 265 Days and 3.8 Hours
Abstract

With the development of technology and accessories, the role of endoscopic ultrasound (EUS) has evolved from diagnostics to therapeutics. In order to characterise the therapeutic role of EUS, we searched Web of Knowledge database and reviewed articles associated with therapeutic EUS. There are two modalities for the therapeutic purpose: drainage and fine-needle injection. EUS-guided drainage is a promising procedure for the treatment of peripancreatic fluid collection and biliary obstruction; EUS-guided fine-needle injections such as celiac plexus neurolysis, for the purpose of pain relief for pancreatic cancer and chronic pancreatitis, has emerged as a promising procedure. The aim of the study was to perform a comprehensive and conscientious review on the techniques, complications and clinical outcomes of those EUS-based procedures.

Keywords: Endoscopic ultrasound; Therapeutic; Biliary drainage; Peripancreatic fluid collection; Celiac plexus neurolysis

Core tip: Endoscopic ultrasound (EUS)-guided interventions have gained popularity in recent years. In this review, EUS-guided peripancreatic fluid collection drainage and biliary drainage are discussed. EUS-guided fine-needle injections, including celiac plexus neurolysis, photodynamic therapy, stereotactic body radiation therapy and ethanol ablation, are also discussed.