Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7842
Peer-review started: January 2, 2015
First decision: January 22, 2015
Revised: February 9, 2015
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: July 7, 2015
AIM: To investigate hepatitis B virus (HBV) prevalence in the general population in China.
METHODS: A total of 148931 individuals were investigated by multistage random sampling in Eastern China. Data were collected on demographics and hepatitis B vaccination history, and serum was tested for hepatitis B surface antigen (HBsAg) by ELISA.
RESULTS: A total of 11469 participants (7.70%, 95%CI: 7.57%-7.84%) were positive for HBsAg. HBsAg prevalence was 0.77% among children < 5 years old but increased progressively from adolescents (1.40%-2.55%) to adults (5.69%-11.22%). A decrease in HBsAg prevalence was strongly associated with vaccination and familial history of HBV among both children and adult groups. Meanwhile, HBsAg risk in adults was associated with invasive testing and sharing needles. The HBV immunization rate among participants aged < 20 years was 93.30% (95%CI: 93.01%-93.58%). Significant difference in HBsAg prevalence appeared between vaccinated and unvaccinated participants (3.59% vs 10.22%).
CONCLUSION: Although the national goal of HBsAg prevalence < 1% among children < 5 years old has been reached, immunization programs should be maintained to prevent resurgence.
Core tip: A total of 148931 individuals were investigated in Eastern China to evaluate the impact of hepatitis B vaccination since 1992. 7.70% were positive for hepatitis B surface antigen (HBsAg) which has not achieved the national goal for the whole population in decreasing the prevalence of HBsAg to < 7%. Prevalence was 0.77% among children aged < 5 years and the rate of hepatitis B virus immunization among teenagers aged < 20 years was 93.30%, which have reached the national goals of < 1% and > 90%, respectively.