Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6764
Peer-review started: November 24, 2014
First decision: December 26, 2014
Revised: January 14, 2015
Accepted: February 5, 2015
Article in press: February 5, 2015
Published online: June 7, 2015
Gastric cancer (GC) is the most prevalent malignancy in the world, especially in China. GC has been postulated to spread via several different routes, including through hematogenous channels, lymphatic vessels, the seeding of peritoneal surfaces, direct extension through the gastric wall, and retrograde extension through the vas deferens or lymphatics. Testicular metastasis is rare. We show here a 53-year-old patient with GC who underwent a radical total gastrectomy approximately 22 mo ago after he presented with a sensation of heaviness and swelling of the right hemiscrotum. The diagnosis of metastatic adenocarcinoma was made after a right-side orchiectomy. We report the first case of testicular metastasis from gastric adenocarcinoma in mainland China and summarize the clinicopathologic features of the disease based on previously published papers.
Core tip: Gastric cancer has been postulated to spread via several different routes, including through hematogenous channels, lymphatic vessels, the seeding of peritoneal surfaces, direct extension through the gastric wall, and retrograde extension through the vas deferens or lymphatics. This paper presents the clinicopathologic features of a case of testicular metastasis from gastric carcinoma in a 53-year-old man. This particular pattern of spread in gastric carcinoma is rare. We report the first such case in mainland China and summarize the clinicopathologic features of the disease based on the current literature .