Meta-Analysis
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2015; 21(18): 5707-5718
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5707
Association of IL-17 polymorphisms with gastric cancer risk in Asian populations
Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Lu Bai
Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Lu Bai, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Author contributions: Long ZW and Yu HM contributed equally to this work; Long ZW, Yu HM, Wang YN, Liu D, Chen YZ, Zhao YX and Bai L designed research; Long ZW, Yu HM and Wang YN performed research; Long ZW and Yu HM contributed new reagents/analytic tools; Long ZW and Yu HM analyzed data; and Long ZW and Yu HM wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ya-Nong Wang, MD, Department of Oncology, Shanghai Medical College, Fudan University, Building 3, Room 1208, 270 Dongan Road, Shanghai 200032, China. wangyanong731@163.com
Telephone: +86-21-64175590 Fax: +86-21-64175590
Received: August 8, 2014
Peer-review started: August 9, 2014
First decision: September 27, 2014
Revised: November 5, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: May 14, 2015
Abstract

AIM: To investigate associations between the IL-17 rs2275913 G>A and rs763780 T>C polymorphisms and susceptibility to gastric cancer in Asian populations.

METHODS: We reviewed studies published up to 2014 on IL-17 polymorphisms with gastric cancer susceptibility systematically. Relevant articles were identified in the MEDLINE, Science Citation Index, Cochrane Library, PubMed, EMBASE, CINAHL and Current Contents Index databases. We used version 12.0 STATA statistical software to evaluate the statistical data. Two reviewers abstracted the data independently. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated.

RESULTS: Seven independent, case-control studies were chosen for the meta-analysis, which included 3210 gastric cancer patients and 3889 healthy controls. The overall estimation showed a positive association between the IL-17 rs2275913 G>A polymorphism and the occurrence of gastric cancer for five genetic models (all P < 0.05) and similar results were observed for the IL-17 rs763780 T>C variation with four genetic models (all P < 0.05), but not for the dominant model (P > 0.05). Subgroup analysis by country revealed that the rs2275913 G>A and rs763780 T>C polymorphisms may be the main risk factor for gastric cancer in Chinese and Japanese populations.

CONCLUSION: The IL-17 gene may be significantly correlated with gastric cancer risk in Asian populations, especially those carrying the rs2275913 G>A and rs763780 T>C polymorphisms.

Keywords: IL-17, Genetic polymorphism, Gastric cancer, Asian populations, Meta-analysis

Core tip: There may be a relationship between the IL-17 gene and gastric cancer risk, especially in individuals carrying the rs2275913 G>A and rs763780 T>C polymorphisms. The IL-17 gene polymorphisms might be important in determining an individual’s susceptibility to gastric cancer.