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World J Gastroenterol. Feb 28, 2014; 20(8): 2005-2013
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.2005
Stereotactic body radiotherapy for oligo-recurrence within the nodal area from colorectal cancer
Young Seok Seo, Mi-Sook Kim, Hyung-Jun Yoo, Won-Il Jang
Young Seok Seo, Mi-Sook Kim, Hyung-Jun Yoo, Won-Il Jang, Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, South Korea
Author contributions: Kim MS and Seo YS wrote the manuscript; Kim MS, Seo YS, Yoo HJ and Jang WI provided the clinical data; all the authors discussed the patient’s outcomes and commented on the manuscript.
Supported by The National Nuclear R and D Program of the Ministry of Science, ICT and Future Planning, South Korea
Correspondence to: Mi-Sook Kim, MD, PhD, Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea. mskim@kcch.re.kr
Telephone: +82-2-9701264 Fax: +82-2-9702412
Received: August 27, 2013
Revised: December 23, 2013
Accepted: January 8, 2014
Published online: February 28, 2014
Abstract

Recurrence of colorectal cancer (CRC) often presents as solitary metastases, oligometastases or oligo-recurrence. Surgical resection became the preferred treatment for patients with CRC lung and hepatic metastases. However, surgical treatment for oligo-recurrence within nodal area is not a widely accepted treatment due to due to their relative rarity and high postoperative morbidity. Stereotactic body radiotherapy (SBRT) is one of the emerging radiation treatment techniques in which a high radiation dose can be delivered to the tumor. High-dose SBRT can ablate the tumor with an efficacy similar to that achieved with surgery, especially for small tumors. However, there have been very few studies on SBRT for oligo-recurrence within nodal area, although several studies have evaluated the role of SBRT in the treatment of liver and lung metastases from CRC. This article reviews the current clinical status of and treatment methods for oligo-recurrence within nodal area from CRC, with particular emphasis on SBRT.

Keywords: Colorectal cancer, Oligo-recurrence, Oligometastases, Stereotactic radiotherapy, Lymph node

Core tip: Surgical treatment for oligo-recurrence of colorectal cancer (CRC) within nodal area is not a widely accepted treatment due to due to their relative rarity and high postoperative morbidity. High-dose stereotactic body radiotherapy (SBRT) can ablate the tumor with an efficacy similar to that achieved with surgery, especially for small tumors. Recently, several investigators successfully treated oligo-recurrence of CRC within nodal area with SBRT. This article reviews the current clinical status of and treatment methods for oligo-recurrence within nodal area from CRC, with particular emphasis on SBRT.