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World J Gastroenterol. Mar 28, 2014; 20(12): 3208-3222
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3208
Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility
Lili Magyari, Erzsebet Kovesdi, Patricia Sarlos, Andras Javorhazy, Katalin Sumegi, Bela Melegh
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Szentagothai Research Centre, 7624 Pecs, Hungary
Patricia Sarlos, 1st Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary
Andras Javorhazy, Department of Urology, University of Pecs, Munkacsy 2, 7621 Pecs, Hungary
Author contributions: Magyari L, Kovesdi E, Sarlos P, Javorhazy A, Sumegi K and Melegh B contributed equally to this work; Melegh B conceived the study; Magyari L and Kovesdi E wrote the genetic part; Sarlos P and Sumegi K wrote the clinical section; Javorhazy A prepared the figures and the table.
Supported by The grant of the Hungarian Science Foundation, No. OTKA K103983
Correspondence to: Bela Melegh, MD, PhD, DSc, Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary. bela.melegh@aok.pte.hu
Telephone: +36-72-536427   Fax: +36-72-536032
Received: September 27, 2013
Revised: December 20, 2013
Accepted: February 20, 2014
Published online: March 28, 2014
Abstract

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD, performing an electronic search of PubMed Database from publications of the last 10 years, and used the following medical subject heading terms and/or text words: IBD, CD, UC, interleukins and polymorphisms.

Keywords: Inflammatory bowel disease, Crohn’s disease, Ulcerative colitis, Interleukin, Interleukin receptor, Polymorphisms

Core tip: Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) are chronic, progressive disorders of the gastrointestinal tract. Different genes, including interleukin genes play central role in mediating and modulating of inflammation in inflammatory bowel diseases. In this review we summarized the interleukin and the interleukin receptor genes associated with Crohn’s disease and/or ulcerative colitis performing an electronic search on the PubMed database focusing on the following terminology: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, interleukin and interleukin receptor.