Han GA, Jiang HM, Zhen XM, Zhou HJ, Xu CZ, Tian JX. Protective effect of various doses of selenium on cadmium-induced hepatic cell damage in pregnant rats. World J Gastroenterol 1996; 2(4): 192-193 [DOI: 10.3748/wjg.v2.i4.192]
Corresponding Author of This Article
Dr. Guo-An Han, Assistant Professor, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shangdong Province, China
Article-Type of This Article
Experimental Papers
Open-Access Policy of This Article
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Guo-An Han, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shangdong Province, China
Hui-Min Jiang, Department of Hygenic Chemistry, Shandong Medical University, Jinan 250012, Shangdong Province, China
Xiu-Mei Zhen, Jinan Railway Central Hospital, Jinan 250012, Shangdong Province, China
Hong-Jun Zhou, Department of Biomedical Engineering, Jinan 250012, Shangdong Province, China
Cai-Zhen Xu, Ji-Xi Tian, Department of pathological Anatomy, Jinan 250012, Shangdong Province, China
Guo-An Han, Assistant Professor, Born in 1939-08-15, Qixia , Shandong Province and graduated in 1966 from Shandong University, primarily engaged in research of the relationship between trace elements and diseases, having 33 papers published and the progect “the interference of trace elements in Cadmium-induced malformation and study of clinical practice” had received the second award of scientific and technical progress by science and technology committees, Shandong, in 1995
Author contributions: All authors contributed equally to the work.
Supported by Project of Shandong Provincial Science and Technology Committee in 1990, No. 95-2-48-1.
Correspondence to: Dr. Guo-An Han, Assistant Professor, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shangdong Province, China
Received: July 26, 1996 Revised: August 15, 1996 Accepted: October 10, 1996 Published online: December 15, 1996
Abstract
AIM: To investigate the protective effect of various doses of selenium (Se) on cadmium (Cd)-induced hepatic cell damage in pregnant rats.
METHODS: The changes in the microstructure and ultrastructure of hepatic cells were observed by microscopy and electron microscopy.
RESULTS: Groups of 16 μg/mL and 8 μg/mL Se had no remarkable protective effects on Cd-induced hepatic cell damage in pregnant rats, while the microstructure and ultrastructure of hepatic cells in the 4 μg/mL Se group were nearly normal.
CONCLUSION: The results show that the antagonism of Se on Cd-induced hepatic cell damage in pregnant rats is related to the dose of Se given. The addictive action of Se and Cd toxicity was found in group B, but group D showed significant protection against Cd-induced damage of hepatic cells.
