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World J Gastroenterol. Jan 28, 2013; 19(4): 440-444
Published online Jan 28, 2013. doi: 10.3748/wjg.v19.i4.440
Published online Jan 28, 2013. doi: 10.3748/wjg.v19.i4.440
MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation
Angélique Gougelet, Sabine Colnot, Institut Cochin, INSERM, U1016, 75014 Paris, France
Angélique Gougelet, Sabine Colnot, Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France
Angélique Gougelet, Sabine Colnot, Université Paris Descartes, Sorbonne Paris Cité, 75013 Paris, France
Author contributions: Gougelet A wrote this paper and Colnot S drafted the final version of the manuscript.
Correspondence to: Angélique Gougelet, PhD, Institut Cochin, INSERM U1016, 24 rue du Faubourg Saint-Jacques, 75014 Paris, France. angelique.gougelet@inserm.fr
Telephone: +33-1-44412567 Fax: +33-1-44412421
Received: July 13, 2012
Revised: October 26, 2012
Accepted: December 15, 2012
Published online: January 28, 2013
Revised: October 26, 2012
Accepted: December 15, 2012
Published online: January 28, 2013
Abstract
A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer.
Keywords: Hepatocyte nuclear factor-4α, MicroRNA, Interleukin-6, Signal transducer and activator of transcription 3, Hepatocellular oncogenesis