Case Report
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World J Gastroenterol. Jan 21, 2013; 19(3): 422-425
Published online Jan 21, 2013. doi: 10.3748/wjg.v19.i3.422
Primary histiocytic sarcoma of the stomach: A case report with imaging findings
Xun-Ze Shen, Fang Liu, Rui-Jun Ni, Bo-Yin Wang
Xun-Ze Shen, Fang Liu, Rui-Jun Ni, Bo-Yin Wang, Department of Radiology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 332100, Zhejiang Province, China
Fang Liu, Department of Pathology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 332100, Zhejiang Province, China
Author contributions: Shen XZ designed the research; Shen XZ and Ni RJ wrote the paper; Shen XZ and Wang BY revised the paper; Liu F analyzed the pathological figures.
Correspondence to: Bo-Yin Wang, Chief Physician, Department of Radiology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 332100, Zhejiang Province, China. sxsrmyyfsk@163.com
Telephone: +86-575-88228548 Fax: +86-575-88228899
Received: September 11, 2012
Revised: November 30, 2012
Accepted: December 15, 2012
Published online: January 21, 2013
Processing time: 132 Days and 9.3 Hours
Abstract

Histiocytic sarcoma (HS) is a rare malignant neoplasm that originates from a histiocytic hematopoietic lineage characterized by histiocytic differentiation and its corresponding immunophenotypic features. We herein reported a case of primary HS of the stomach which was confirmed through histopathologic examination and immunohistochemical staining. A 52-year-old woman presented with progressive difficulty in feeding and dull pain in the epigastric region. Gastroscopy, endoscopic ultrasonography, double contrast examination, and computed tomography revealed a mass located on the posterior wall of fundus and lesser curvature of the stomach. Microscopically, the cytoplasm of the tumor cells was abundant and eosinophilic. Immunohistochemical staining revealed that the tumor cells were positive for CD45RO and CD68. It is difficult to differentiate HS of stomach from other gastric malignancies by radiological evaluation alone. However, HS may be considered when a protruding and ulcerated mass in stomach shows heterogeneous hypervascular features. To the best of our knowledge, this is the first report in English language literature that emphasizes the imaging findings of human gastric HS.

Keywords: Histiocytic sarcoma; Stomach; Primary; Endoscopic ultrasonography; Gastroscope; Double contrast examination; Computed tomography