Brief Article
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World J Gastroenterol. May 28, 2013; 19(20): 3117-3123
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3117
Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach
Rong Cai, Gang Ren, Deng-Bin Wang
Rong Cai, Department of Radiochemotherapy, Rui Jin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China
Gang Ren, Deng-Bin Wang, Department of Radiology, Xin Hua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China
Author contributions: Cai R and Ren G contributed equally to this paper; Cai R and Ren G performed the data acquisition, analysis, data statistical and interpretation; Ren G and Wang DB designed the study and wrote the manuscript.
Supported by Shanghai Jiaotong University Medical School for Scientific Research, No. 09XJ21013; Shanghai Health Bureau for Scientific Research, No. 2010029; Shanghai Science and Technology Commission for Scientific Research, No. 124119a0300
Correspondence to: Deng-Bin Wang, MD, PhD, Department of Radiology, Xin Hua Hospital, Shanghai Jiaotong University Medical School, 1665 Kongjiang Road, Shanghai 200092, China. dbwang8@yahoo.com.cn
Telephone: +86-21-25078999 Fax: +86-21-65030840
Received: January 6, 2013
Revised: April 19, 2013
Accepted: May 9, 2013
Published online: May 28, 2013
Processing time: 142 Days and 11.4 Hours
Abstract

AIM: To review the clinicopathological characteristics of concurrent gastrointestinal stromal tumors (GISTs) and gastric adenocarcinoma.

METHODS: We retrospectively analyzed eight cases of synchronous adenocarcinoma and GIST in the stomach that had been surgically resected with curative intent between March 2003 and December 2008 in Xinhua hospital and Ruijin hospital. The adenocarcinoma was determined to be the primary tumor based on the histological features. The GIST cells were diffusely and strongly positive for CD34 and CD117.

RESULTS: The patients were six men and two women aged 47-80 years (average, 68.6 years). GIST was preoperatively detected in only one patient. The average sizes of the gastric adenocarcinomas and GISTs were 6.000 ± 2.6186 cm and 1.825 ± 1.4370 cm, respectively. All GISTs were very low- or low-risk lesions that were detected during evaluation, staging, operation or follow-up for gastric adenocarcinoma.

CONCLUSION: We hypothesized that the stomach was influenced by the same unknown carcinogen, resulting in a simultaneous proliferation of different cell lines (epithelial and stromal cell).

Keywords: Gastric adenocarcinoma; Gastrointestinal stromal tumor; Synchronous occurrence; Gastrectomy

Core tip: We retrospectively analyzed eight cases of synchronous adenocarcinoma and gastrointestinal stromal tumors (GISTs) in the stomach that had been surgically resected with curative intent between March 2003 and December 2008 in Xinhua hospital and Ruijin hospital. The average sizes of the gastric adenocarcinomas and GISTs were 6.000 ± 2.6186 cm and 1.825 ± 1.4370 cm, respectively. All GISTs were very low- or low-risk lesions that were detected during evaluation, staging, operation or follow-up for gastric adenocarcinoma. We hypothesized that the stomach was influenced by the same unknown carcinogen, resulting in a simultaneous proliferation of different cell lines (epithelial and stromal cell).