Almeida PR, Ferreira FV, Santos CC, Rocha-Filho FD, Feitosa RR, Falcão EA, Cavada BK, Lima-Júnior RC, Ribeiro RA. Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases. World J Gastroenterol 2012; 18(8): 778-784 [PMID: 22371637 DOI: 10.3748/wjg.v18.i8.778]
Corresponding Author of This Article
Paulo RC Almeida, PhD, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Rua Monsenhor Furtado S/N - Rodolfo Teófilo, 60.430-350 Fortaleza, Brazil. paulo.almeida@ufc.br
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Brief Article
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World J Gastroenterol. Feb 28, 2012; 18(8): 778-784 Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.778
Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases
Paulo RC Almeida, Francisco VA Ferreira, Cássio C Santos, Francisco D Rocha-Filho, Raul RP Feitosa, Esther AA Falcão, Belise K Cavada, Roberto CP Lima-Júnior, Ronaldo A Ribeiro
Paulo RC Almeida, Raul RP Feitosa, Esther AA Falcão, Belise K Cavada, Roberto CP Lima-Júnior, Ronaldo A Ribeiro, Faculty of Medicine, Federal University of Ceará, 60.430-350 Fortaleza, Brazil
Francisco VA Ferreira, Cássio C Santos, Francisco D Rocha-Filho, Ronaldo A Ribeiro, Hospital of Cancer, Cancer Institute of Ceará, 60.430-350 Fortaleza, Brazil
Author contributions: Almeida PRC, Ferreira FVA, Santos CC, Rocha-Filho FD and Ribeiro RA contributed to the conception and design, analysis and interpretation of data; Feitosa RRP, Falcão EAA and Cavada BK performed the acquisition of data; Almeida PRC, Lima-Júnior RCP and Ribeiro RA wrote and revised the article; and all the authors approved the final version to be published.
Supported by Institute of Molecular Pathology and Immunology of the University of Porto; Coordination for the Development of Post-Graduation Programs; and National Council for Scientific and Technological Development
Correspondence to: Paulo RC Almeida, PhD, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Rua Monsenhor Furtado S/N - Rodolfo Teófilo, 60.430-350 Fortaleza, Brazil. paulo.almeida@ufc.br
Telephone: +55-85-33668300 Fax: +55-85-33668316
Received: January 27, 2011 Revised: March 24, 2011 Accepted: March 31, 2011 Published online: February 28, 2012
Abstract
AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases.
METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma.
RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108).
CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.
