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World J Gastroenterol. Feb 28, 2012; 18(8): 746-753
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.746
Routine blood tests to predict liver fibrosis in chronic hepatitis C
Yung-Yu Hsieh, Shui-Yi Tung, Kamfai Lee, Cheng-Shyong Wu, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Yi-Hsiung Lin
Yung-Yu Hsieh, Shui-Yi Tung, Cheng-Shyong Wu, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
Yung-Yu Hsieh, Shui-Yi Tung, Cheng-Shyong Wu, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Chang Gung University College of Medicine, Taoyuan 333, Taiwan
Shui-Yi Tung, Cheng-Shyong Wu, Chiayi School, Chang Gung Institute of Technology, Chiayi 613, Taiwan
Kamfai Lee, Department of Pathology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
Yi-Hsiung Lin, Department of Health Care Administration, Taiwan Shoufu University, Tainan 721, Taiwan
Author contributions: Hsieh YY and Tung SY designed the research; Hsieh YY, Tung SY, Wu CS, Wei KL, Shen CH and Chang TS collected all the human material; Lee K performed the histological assessment; Hsieh YY and Lin YH performed the statistical analysis; and Hsieh YY and Tung SY wrote the paper.
Supported by Clinical Study Project XMRP, No. CMRPG 690081, from Chiayi Chang Gung Memorial Hospital
Correspondence to: Shui-Yi Tung, MD, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, 6 Section West, Chia-Po Road, Putz City, Chiayi 613, Taiwan. ma1898@adm.cgmh.org.tw
Telephone: +886-5-3621000 Fax: +886-5-3623005
Received: March 23, 2011
Revised: May 26, 2011
Accepted: May 30, 2011
Published online: February 28, 2012
AIM: To verify the usefulness of FibroQ for predicting fibrosis in patients with chronic hepatitis C, compared with other noninvasive tests.
METHODS: This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratio index, cirrhosis discriminant score, age-platelet index (API), Pohl score, FIB-4 index, and Lok’s model were calculated and compared.
RESULTS: FibroQ, FIB-4, AAR, API and Lok’s model results increased significantly as fibrosis advanced (analysis of variance test: P < 0.001). FibroQ trended to be superior in predicting significant fibrosis score in chronic hepatitis C compared with other noninvasive tests.
CONCLUSION: FibroQ is a simple and useful test for predicting significant fibrosis in patients with chronic hepatitis C.
