Case Report
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Dec 14, 2012; 18(46): 6861-6864
Published online Dec 14, 2012. doi: 10.3748/wjg.v18.i46.6861
Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma
Qing He, An-Ren Kuang, Yong-Song Guan, Yue-Qing Liu
Qing He, Yong-Song Guan, Yue-Qing Liu, Department of Oncology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
An-Ren Kuang, Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: He Q and Kuang AR conceived and designed the study and prepared the manuscript; Guan YS and Liu YQ acquired and analyzed the data.
Correspondence to: Dr. An-Ren Kuang, Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. he41@sohu.com
Telephone: +86-28-85423270 Fax: +86-28-85423278
Received: July 22, 2012
Revised: September 11, 2012
Accepted: September 19, 2012
Published online: December 14, 2012
Abstract

Hepatocellular carcinoma (HCC) is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) because they were considered neither effective nor safe. Currently, there is almost no effective treatment for HCC of such condition. As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide (PTS) produces mild side effects while necrotizing the tumor tissues quickly and efficiently. Being largely different from both PEI and RFA therapies, PTS can disseminate itself in tumors more easily than other caustic agents, such as alcohol. So PTS may offer additional benefit to HCCs with vascular involvement. We herein describe a 70-year-old HCC patient who was treated with the combination of PTS injection and transcatheter arterial chemoembolization, resulting in a significantly improved clinical prognosis.

Keywords: Hepatocellular carcinoma; Para-toluenesulfonamide; Antitumor agent; Transcatheter arterial chemoembolization; Therapy