Cai N, Ji GZ, Fan ZN, Wu YF, Zhang FM, Zhao ZF, Xu W, Liu Z. Association between body mass index and erosive esophagitis: A meta-analysis. World J Gastroenterol 2012; 18(20): 2545-2553 [PMID: 22654453 DOI: 10.3748/wjg.v18.i20.2545]
Corresponding Author of This Article
Zheng Liu, MD, PhD, Department of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China. liuzheng117@126.com
Article-Type of This Article
Brief Article
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World J Gastroenterol. May 28, 2012; 18(20): 2545-2553 Published online May 28, 2012. doi: 10.3748/wjg.v18.i20.2545
Association between body mass index and erosive esophagitis: A meta-analysis
Nan Cai, Guo-Zhong Ji, Zhi-Ning Fan, Yan-Feng Wu, Fa-Ming Zhang, Zhi-Fei Zhao, Wei Xu, Zheng Liu
Nan Cai, Guo-Zhong Ji, Zhi-Ning Fan, Fa-Ming Zhang, Zhi-Fei Zhao, Wei Xu, Zheng Liu, Department of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China
Yan-Feng Wu, Department of Neurology, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China
Author contributions: Cai N designed the study, wrote the paper and reviewed all articles for inclusion with Wu YF; Liu Z performed the final consensus review and the final data analysis; and all authors contribute to this study and approved the final version to be published.
Correspondence to: Zheng Liu, MD, PhD, Department of Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China. liuzheng117@126.com
Telephone: +86-25-58509883 Fax: +86-25-58509883
Received: August 6, 2011 Revised: March 2, 2012 Accepted: April 28, 2012 Published online: May 28, 2012
Abstract
AIM: To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE) and body mass index (BMI).
METHODS: We identified the studies using PubMed. Studies were selected for analysis based on certain inclusion and exclusion criteria. Data were extracted from each study on the basis of predefined items. Meta-analyses were performed to verify the risk factors, such as obesity and gender.
RESULTS: Twenty-one studies were included in this systematic review. These studies demonstrated an association between increasing BMI and the presence of EE [95% confidence interval (CI): 1.35-1.88, overweight, odds ratio (OR) = 1.60, P value homogeneity = 0.003, 95% CI: 1.65-2.55, obese, OR = 2.05, P < 0.01]. The heterogeneity disappeared by stratifying for gender. No publication bias was observed in this meta-analysis by the Egger method.
CONCLUSION: This analysis demonstrates a positive association between BMI and the presence of EE, especially in males. The risk seems to progressively increase with increasing weight.
