Brief Article
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World J Gastroenterol. May 21, 2012; 18(19): 2377-2382
Published online May 21, 2012. doi: 10.3748/wjg.v18.i19.2377
Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection
Hyuk Soon Choi, Hoon Jai Chun, Sang Hoon Park, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon-Tae Jeen, Soon Ho Um, Hong Sik Lee, Chang Duck Kim, Ho Sang Ryu
Hyuk Soon Choi, Hoon Jai Chun, Sang Hoon Park, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon-Tae Jeen, Soon Ho Um, Hong Sik Lee, Chang Duck Kim, Ho Sang Ryu, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul 136-705, South Korea
Author contributions: Choi HS and Park SH designed the study and acquired the data; Keum B, Seo YS and Kim YS analyzed the data; Choi HS drafted the paper; Jeen YT, Um SH, Lee HS, Kim CD and Ryu HS revised it critically; Chun HJ reviewed and edited the manuscript and approved the final version.
Correspondence to: Hoon Jai Chun, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, South Korea. drchunhj@chol.com
Telephone: +82-2-9206555 Fax: +82-2-9531943
Received: September 14, 2011
Revised: April 7, 2012
Accepted: April 10, 2012
Published online: May 21, 2012
Abstract

AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations.

METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.

RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively).

CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.

Keywords: Helicobacter pylori, Sequential therapy, Triple therapy, Gastric ulcer, Duodenal ulcer, Gastritis