Case Report
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 21, 2011; 17(43): 4835-4838
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4835
Lipomatous hemangiopericytoma of the stomach: A case report and a review of literature
Hong-Biao Jing, Qing-Da Meng, Yan-Hong Tai
Hong-Biao Jing, Department of Pathology, The General Hospital, Jinan Military Command, Jinan 250031, Shandong Province, China
Qing-Da Meng, Department of Pathology, The Zhangqiu City Hospital, Zhangqiu 250200, Shandong Province, China
Yan-Hong Tai, Department of Pathology, The PLA General Hospital, Beijing 100853, China
Author contributions: Jing HB designed the study; Meng QD and Tai YH performed data collection and analysis; Jing HB and Tai YH wrote the paper.
Correspondence to: Hong-Biao Jing, MD, Department of Pathology, The General Hospital, Jinan Military Command, Shifan Road 25, Jinan 250031, Shandong Province, China.
Telephone: +86-0531-51666857 Fax: +86-0531-51666284
Received: May 2, 2011
Revised: June 21, 2011
Accepted: June 29, 2011
Published online: November 21, 2011

Lipomatous hemangiopericytomas (LHPCs) are rare soft-tissue tumors that are histologically characterized by hemangiopericytomatous vasculature and the presence of mature adipocytes. We present the clinicopathological features of a case of gastric LHPC in a 56-year-old female, along with a literature review. Endoscopy and endoscopic ultrasound showed a submucosal tumor 0.8 cm across in the greatest dimension in the lesser curvature side of the gastric antrum. Grossly, the well-defined mass had a solid and tan-white cut surface admixed with myxoid regions and yellowish areas. Histological examination revealed a submucosal well-circumscribed lesion composed of cellular nodules with the classic appearance of an hemangiopericytoma admixed with clusters and lobules of mature adipocytes. The ill-defined tumor cells had weakly eosinophilic cytoplasm and contained spindled nuclei with occasional small nucleoli. Nuclei atypia and mitoses were absent, and no cellular atypia, necrosis or vascular invasion was observed. Immunohistochemistry showed that the tumor cells were diffusely positive for CD34, CD99, and vimentin and were focally reactive for bcl-2. This is the first known report of an LHPC in the stomach. The patient was followed for 12 mo without any evidence of metastasis or recurrence.

Keywords: Lipomatous hemangiopericytoma, Hemangiopericytoma, Solitary fibrous tumor, Stomach, Immunohistochemistry