Brief Article
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World J Gastroenterol. Nov 21, 2011; 17(43): 4793-4798
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4793
Analysis of ABC (D) stratification for screening patients with gastric cancer
Tomohiro Kudo, Satoru Kakizaki, Naondo Sohara, Yasuhiro Onozato, Shinichi Okamura, Yoshikatsu Inui, Masatomo Mori
Tomohiro Kudo, Satoru Kakizaki, Shinichi Okamura, Masatomo Mori, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan
Naondo Sohara, Yasuhiro Onozato, Department of Endoscopy and Endoscopic Surgery, Shirakawa Clinic, Maebashi, Gunma 371-8511, Japan
Yoshikatsu Inui, Inui Clinic of Internal Medicine, Takasaki, Gunma 371-8511, Japan
Author contributions: Kudo T, Sohara N and Onozato Y performed the majority of experiments and collected data; Kakizaki S designed the study and wrote the manuscript; Okamura S, Inui Y and Mori M gave vital suggestions.
Correspondence to: Satoru Kakizaki, MD, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Telephone: +81-27-2208127 Fax: +81-27-2208136
Received: February 21, 2011
Revised: June 9, 2011
Accepted: June 13, 2011
Published online: November 21, 2011

AIM: To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer.

METHODS: Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylori antibody levels were measured. Patients were classified into five groups of ABC (D) stratification according to their serological status. Endoscopic findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC (D) stratification.

RESULTS: The mean patient age was (67.9 ± 8.9) years. Three patients (3.2%) were classified into group A, 7 patients (7.4%) into group A’, 27 patients (28.4%) into group B, 54 patients (56.8%) into group C, and 4 patients (4.2%) into group D, respectively. There were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for H. pylori (group A’) were excluded. These three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC (D) stratification. Histologically, the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma (P < 0.05). There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated groups.

CONCLUSION: ABC (D) stratification is a good method for screening patients with gastric cancers. Endoscopy is needed for grey zone cases to check the extent of mucosal atrophy.

Keywords: Gastric cancer, Helicobacter pylori, Pepsinogen, ABC (D) stratification, Cancer screening