Copyright
©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 7, 2011; 17(41): 4632-4634
Published online Nov 7, 2011. doi: 10.3748/wjg.v17.i41.4632
Published online Nov 7, 2011. doi: 10.3748/wjg.v17.i41.4632
S-1 induced secondary acute erythroid leukemia with a chromosome inv(12)(p13;q13)
Kensuke Matsumoto, Makiko Uemura, Fusako Waki, Tetsuya Fukumoto, Hiroaki Ohnishi, Toshihiko Ishida, First Department of Internal Medicine, Faculty of Medicine, Kagawa Univesity, 1750-1 Miki-cho, Kita-gun, Kagawa prefecture 761-0793, Japan
Akira Kitanaka, Hematology, Faculty of Medicine, Kagawa Univesity, 1750-1, Miki-cho, Kita-gun, Kagawa prefecture 761-0793, Japan
Yoshitsugu Kubota, Department of Transfusion Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Kagawa prefecture 761-0793, Japan
Author contributions: Matsumoto K, Kitanaka A contributed equally to this work; Uemura M, Waki F, Fukumoto T, Ohnishi H, Kubota Y, Ishida T designed research; Matsumoto K and Kitanaka A wrote the paper.
Correspondence to: Kensuke Matsumoto, MD, PhD, First Department of Internal Medicine, Faculty of Medicine, Kagawa Univesity, 1750-1, Miki-cho, Kita-gun, Kagawa prefecture, Japan. matsumot@med.kagawa-u.ac.jp
Telephone: +81-87-8912145 Fax: +81-87-8912147
Received: January 5, 2011
Revised: March 7, 2011
Accepted: March 14, 2011
Published online: November 7, 2011
Revised: March 7, 2011
Accepted: March 14, 2011
Published online: November 7, 2011
Abstract
Adjuvant chemotherapy by S-1 following gastrectomy is considered standard treatment in Japan. Analysis of follow-up data have proved the efficacy of S-1 administration, and that hematological adverse events were relatively rare. Pyrimidine anti-metabolites, including S-1, have shown relatively lower risks for secondary hematological malignancies in comparison to alkylating agents and topoisomerase-II inhibitors. We here report a case of therapy-related leukemia after S-1 administration. A patient who had received S-1as the sole adjuvant chemotherapy was diagnosed with acute erythroid leukemia. To the best of our knowledge, our patient represents the first report of S-1 induced acute leukemia.
Keywords: S-1, Secondary leukemia, Acute erythroid Leukemia, Gastric cancer