Risk factors for hilar cholangiocarcinoma: A case-control study in China

doi:10.3748/wjg.v17.i2.249

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2011; 17(2): 249-253
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.249

Risk factors for hilar cholangiocarcinoma: A case-control study in China

Wen-Ke Cai, Hui Sima, Ben-Dong Chen, Guang-Shun Yang

Wen-Ke Cai, Hui Sima, Ben-Dong Chen, Guang-Shun Yang, Department of Biliary Surgery II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

Author contributions: Cai WK and Yang GS designed the research; Cai WK, Sima H and Chen BD performed the research and analyzed the data; Cai WK and Yang GS wrote the paper.

Correspondence to: Guang-Shun Yang, Professor, Department of Biliary Surgery II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. caiwenke002@126.com

Telephone: +86-21-81875292 Fax: +86-21-81875291

Received: August 24, 2010
Revised: September 26, 2010
Accepted: October 3, 2010
Published online: January 14, 2011

Abstract

AIM: To study the association between hilar cholangiocarcinoma (HC) and pre-existing medical conditions.

METHODS: Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) in 2000-2005 and 608 healthy controls were enrolled in this study. Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio (OR) calculated by logistic regression analysis.

RESULTS: The prevalence of choledocholithiasis (adjusted OR = 2.704, P = 0.039), hepatolithiasis (adjusted OR = 3.278, P = 0.018), cholecystolithiasis (adjusted OR = 4.499, P < 0.0001), cholecystectomy (adjusted OR = 7.012, P = 0.004), biliary ascariasis (adjusted OR = 7.188, P = 0.001), liver fluke (adjusted OR = 10.088, P = 0.042) and liver schistosomiasis (adjusted OR = 9.913, P = 0.001) was higher in HC patients than in healthy controls.

CONCLUSION: Biliary tract stone disease (choledocholithiasis, hepatolithiasis, cholecystolithiasis) and parasitic liver disease (biliary ascariasis, liver fluke, liver schistosomiasis) are the risk factors for HC in Chinese population.

Keywords: Hilar cholangiocarcinoma, Choledocholithiasis, Hepatitis B virus, Hepatitis C virus, Liver fluke