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World J Gastroenterol. May 7, 2011; 17(17): 2172-2177
Published online May 7, 2011. doi: 10.3748/wjg.v17.i17.2172
Mallory-Denk Bodies in chronic hepatitis
Metin Basaranoglu, Nesrin Turhan, Abdullah Sonsuz, Gökcen Basaranoglu
Metin Basaranoglu, Gastroenterology and Hepatology, Consulting, Endoscopy, Ankara Yüksek Ihtisas Hospital, Ankara, 06420, Turkey
Nesrin Turhan, Department of Pathology, Ankara Yüksek Ihtisas Hospital, Ankara, 06420, Turkey
Abdullah Sonsuz, Gastroenterology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, 34500, Turkey
Gökcen Basaranoglu, Department of Anaesthesiology, Vakif Gureba University Hospital, Istanbul, 34500, Turkey
Author contributions: Basaranoglu M contributed extensively to the work, performed literature search and designed and wrote the paper; Turhan N provided pathology results of the patients; Turhan N, Sonsuz A and Basaranoglu G commented on the paper.
Correspondence to: Metin Basaranoglu, MD, Gastroenterology and Hepatology, Consulting, Endoscopy, Ankara Yüksek Ihtisas Hospital, Ankara, 06420, Turkey. metin_basaranoglu@yahoo.com
Telephone: +90-312-5878030 Fax: +90-212-5540570
Received: September 11, 2010
Revised: December 9, 2010
Accepted: December 16, 2010
Published online: May 7, 2011
Abstract

Mallory-Denk Bodies (MDB) are important as investigators, suggesting MDB as an indicator of the histologic severity of chronic hepatitis, causes of which include hepatitis C, primary biliary cirrhosis (PBC), and nonalcoholic fatty liver disease (NAFLD). Matteoni et al scored MDB in patients with NAFLD as none, rare and many, and reported that MDB plays a prominent role in this classification scheme in an earlier classification system. In this study, we evaluated 258 patients with chronic hepatitis due to metabolic, autoimmune and viral etiologies. Liver biopsy samples were evaluated with hematoxylin and eosin, periodic acid-Schiff-diastase, Gordon and Sweet’s reticulin, Masson’s trichrome, and iron stains. Both staging and grading were performed. Additionally, MDB were evaluated and discussed for each disease. We examined patients with nonalcoholic steatohepatitis (NASH; 50 patients), alcoholic hepatitis (10 patients), PBC (50 patients), Wilson disease (WD; 20 patients), hepatitis B (50 patients), hepatitis C (50 patients) and hepatocellular carcinoma (HCC; 30 patients). Frequency of MDB was as follows; NASH: 10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone 3. PBC: 11 patients with mild in 10%, moderate in 70%, and cirrhosis in 20%, and frequently seen in zone 1. WD: 16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone 1. Hep B: 3 patients with mild in 66% and severe in 34%. Hep C: 7 patients with mild in 40% and moderate in 60% and observed in every stage. HCC: 3 patients with hep B in 2 patients. We found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology.

Keywords: Non-alcoholic fatty liver disease, Mallory-Denk Bodies, Hepatitis B and C, Hepatocellular carcinoma, Primary biliary cirrhosis, Wilson disease