Li JQ, Chen J, Liu NN, Yang L, Zeng Y, Wang B, Wang XR. Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer. World J Gastroenterol 2011; 17(16): 2131-2136 [PMID: 21547134 DOI: 10.3748/wjg.v17.i16.2131]
Corresponding Author of This Article
Xue-Rong Wang, PhD, Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. binwang@njmu.edu.cn
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Brief Article
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World J Gastroenterol. Apr 28, 2011; 17(16): 2131-2136 Published online Apr 28, 2011. doi: 10.3748/wjg.v17.i16.2131
Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer
Jia-Qi Li, Jie Chen, Nan-Nan Liu, Li Yang, Ying Zeng, Bin Wang, Xue-Rong Wang
Jia-Qi Li, Jie Chen, Nan-Nan Liu, Ying Zeng, Bin Wang, Xue-Rong Wang, Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Li Yang, Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Yang L, Zeng Y, Wang B and Wang XR designed the research and enrolled the patients; Li JQ, Chen J and Liu NN performed the research; Li JQ analyzed the data; Li JQ wrote the paper.
Supported by Grants from the National Natural Science Foundation of China, No. 30672486; the Natural Science Foundation of Jiangsu Province, No. BK2006525; “333 Project” and “Qinglan Project” Funds for the Young Academic Leader of Jiangsu Province to Wang B
Correspondence to: Xue-Rong Wang, PhD, Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. binwang@njmu.edu.cn
Telephone: +86-25-86862884 Fax: +86-25-86862884
Received: December 12, 2009 Revised: January 20, 2010 Accepted: January 27, 2010 Published online: April 28, 2011
Abstract
AIM: To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.
METHODS: In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS: The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.
CONCLUSION: The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.
