Darvish-Damavandi M, Nikfar S, Abdollahi M. A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. World J Gastroenterol 2010; 16(5): 547-553 [PMID: 20128021 DOI: 10.3748/wjg.v16.i5.547]
Corresponding Author of This Article
Mohammad Abdollahi, Professor, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, and Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. mohammad@tums.ac.ir
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Review
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World J Gastroenterol. Feb 7, 2010; 16(5): 547-553 Published online Feb 7, 2010. doi: 10.3748/wjg.v16.i5.547
A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome
Mahnaz Darvish-Damavandi, Shekoufeh Nikfar, Mohammad Abdollahi
Mahnaz Darvish-Damavandi, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Shekoufeh Nikfar, Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Food & Drug Laboratory Research Center, Deputy for Food & Drug Affairs, Ministry of Health & Medical Education, Tehran 1417614411, Iran
Mohammad Abdollahi, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, and Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Author contributions: Darvish-Damavandi M searched the literature, read the papers, gathered the data and drafted the manuscript; Nikfar S reviewed the papers, conducted the meta-analysis and reviewed the manuscript; Abdollahi M conceived the study, supervised/reviewed the entire study and edited the manuscript.
Correspondence to: Mohammad Abdollahi, Professor, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, and Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. mohammad@tums.ac.ir
Telephone: +98-21-66959104 Fax: +98-21-66959104
Received: October 15, 2009 Revised: January 4, 2010 Accepted: January 11, 2010 Published online: February 7, 2010
Abstract
We evaluated the efficacy and tolerability of mebeverine, a musculotropic antispasmodic agent, in irritable bowel syndrome (IBS) and compared its usual dosages by meta-analysis. Medical databases and all relevant literature were searched from 1965 to June 2009 for any placebo-controlled clinical trials of mebeverine, using search terms such as mebeverine, clinical trials, and IBS. Eight randomized trials met our criteria, including six trials that compared mebeverine with placebo and two that compared mebeverine tablets with capsules. These eight trials included 555 patients randomized to receive either mebeverine or placebo with 352 (63%) women and 203 (37%) men in all subtypes of IBS. The pooled relative risk (RR) for clinical improvement of mebeverine was 1.13 (95% CI: 0.59-2.16, P = 0.7056) and 1.33 (95% CI: 0.92-1.93, P = 0.129) for relief of abdominal pain. The efficacy of mebeverine 200 mg compared to mebeverine 135 mg indicated RRs of 1.12 (95% CI: 0.96-1.3, P = 0.168) for clinical or global improvement and 1.08 (95% CI: 0.87-1.34, P = 0.463) for relief of abdominal pain. Thus, mebeverine is mostly well tolerated with no significant adverse effects; however, its efficacy in global improvement of IBS is not statistically significant.
