Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. Jan 28, 2010; 16(4): 508-512
Published online Jan 28, 2010. doi: 10.3748/wjg.v16.i4.508
Application of contrast-enhanced intraoperative ultrasonography in the decision-making about hepatocellular carcinoma operation
Hong Wu, Qiang Lu, Yan Luo, Xian-Lu He, Yong Zeng
Hong Wu, Xian-Lu He, Yong Zeng, Department of Hepato-Biliary-Pancreatic surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Qiang Lu, Yan Luo, Department of sonography, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wu H and Luo Y designed the research; Wu H, He XL, Zeng Y performed the surgery; Lu Q and Luo Y did the ultrasound scans; Wu H and Lu Q wrote the paper.
Correspondence to: Yong Zeng, Professor, Department of Hepato-Biliary-Pancreatic surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. zengyong@medmail.com
Telephone: +86-28-85422868 Fax: +86-28-85422475
Received: September 6, 2009
Revised: November 19, 2009
Accepted: November 26, 2009
Published online: January 28, 2010
Abstract

AIM: To evaluate the detection and differentiation ability of contrast-enhanced intraoperative ultrasonography (CE-IOUS) in hepatocellular carcinoma (HCC) operations.

METHODS: Clinical data of 50 HCC patients were retrospective analyzed. The sensitivity, specificity, false negative and false positive rates of contrast enhanced magnetic resonance imaging (CE-MRI), IOUS and CE-IOUS were calculated and compared. Surgical strategy changes due to CE-IOUS were analyzed.

RESULTS: Lesions detected by CE-MRI, IOUS and CE-IOUS were 60, 97 and 85 respectively. The sensitivity, specificity, false negative rate, false positive rate of CE-MRI were 98.2%, 98.6%, 98.6%, 60.0%, respectively; for IOUS were 50.0%, 90.9%, 1.8%, 1.4%, respectively; and for CE-IOUS were 1.4%, 40.0%, 50.0%, 9.1%, respectively. The operation strategy of 9 (9/50, 18.0%) cases was changed according to the results of CE-IOUS.

CONCLUSION: Compared with CE-MRI, CE-IOUS performs better in detection and differentiation of small metastasis and regenerative nodules. It plays an important role in the decision-making of HCC operation.

Keywords: Hepatocellular carcinoma, Liver resection, Contrast enhanced magnetic resonance imaging, Intraoperative ultrasonography, Contrast-enhanced intraoperative ultrasonography