Brief Article
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World J Gastroenterol. Sep 28, 2010; 16(36): 4616-4620
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4616
Clinicopathological features of gastric glomus tumor
Hui-Qiong Fang, Jing Yang, Fen-Fen Zhang, Yi Cui, An-Jia Han
Hui-Qiong Fang, Jing Yang, Fen-Fen Zhang, An-Jia Han, Department of Pathology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Hui-Qiong Fang, Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, Guangdong Province, China
Jing Yang, Department of Pathology, People’s Hospital of Zhuhai City, Zhuhai 519000, Guangdong Province, China
Yi Cui, Department of Gastroenterology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Fang HQ, Yang J, Zhang FF and Cui Y collected the clinical data; Fang HQ wrote the manuscript; Han AJ designed this study and revised the manuscript.
Correspondence to: An-Jia Han, MD, PhD, Department of Pathology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. hananjia@mail.sysu.edu.cn
Telephone: +86-20-87331780 Fax: +86-20-87331780
Received: May 15, 2010
Revised: August 3, 2010
Accepted: August 10, 2010
Published online: September 28, 2010
Abstract

AIM: To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.

METHODS: A case of gastric glomus tumor was reported. Clinicopathological findings in 56 cases of gastric glomus tumor were analyzed.

RESULTS: Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:1. The median age of the patients was 45 years (range 28-79 years). The patients often complained of epigastric pain and bloody stool. The tumor was located in antrum of the stomach. The greatest diameter of the tumor was 0.8-11cm. Histologically, the tumor was comprised of nests of glomus cells surrounding the capillaries. Glomus cells were small, uniform and round. Vimentin, smooth muscle actin and actin were expressed in the tumor. Other markers, including S-100 protein, CD34, CD117, desmin, CD56, synaptophysin, chromogranin A, neuron specific enolase and cytokeratin were all negative.

CONCLUSION: Gastric glomus tumor is a rare benign mesenchymal neoplasm. Its diagnosis depends on pathologic examination. Differential diagnosis includes gastrointestinal stromal tumor, paraganglioma and carcinoid tumor.

Keywords: Stomach, Glomus tumor, Clinicopathology, Immunohistochemistry