Brief Article
Copyright ©2010 Baishideng. All rights reserved
World J Gastroenterol. Jul 21, 2010; 16(27): 3450-3456
Published online Jul 21, 2010. doi: 10.3748/wjg.v16.i27.3450
Radiofrequency ablation in the treatment of small hepatocellular carcinoma: A meta analysis
Jun-Guo Liu, Yi-Jun Wang, Zhi Du
Jun-Guo Liu, Yi-Jun Wang, Zhi Du, Department of Hepatobiliary Surgery, Third Central Hospital, Tianjin 300170, China
Zhi Du, The Key Laboratory of Artificial Cells, Tianjin 300170, China
Author contributions: Du Z and Wang YJ designed the research and revised the manuscript; Du Z, Wang YJ and Liu JG performed the research and provided the analytic tools; Liu JG collected the clinical pathological data and analyzed the data and wrote the manuscript.
Correspondence to: Zhi Du, MD, Department of Hepatobiliary Surgery, Third Central Hospital, Tianjin 300170, China. zhi-du@163.com
Telephone: +86-22-84112087 Fax: +86-22-24315132
Received: March 31, 2010
Revised: April 28, 2010
Accepted: May 5, 2010
Published online: July 21, 2010
Abstract

AIM: To evaluate survival and recurrence after radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) using a meta-analysis.

METHODS: Literature on RFA vs surgical resection for the treatment of small HCC published between January 1990 and December 2008 was retrieved. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. A fixed or random effect model was established to collect the data.

RESULTS: The differences in overall survival at 1-year, 3-years and at end of follow-up were not statistically significant between the RFA and surgery groups (P > 0.05). There were no differences in 1-year and 3-year recurrences between the RFA and surgery groups (P > 0.05). However, recurrence in the RFA group was lower than that in the surgery group up to the end of follow-up (P = 0.03). Survival was not significantly different. There was a significant difference in recurrences at the end of follow-up after RFA compared with surgical resection.

CONCLUSION: RFA did not decrease the number of overall recurrences, and had no effect on survival when compared with surgical resection in a selected group of patients.

Keywords: Hepatectomy, Hepatocellular carcinoma, Meta-analysis, Radiofrequency ablation, Recurrence, Survival