Park HS, Kim YJ, Yang WI, Suh CO, Lee YC. Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma. World J Gastroenterol 2010; 16(17): 2158-2162 [PMID: 20440857 DOI: 10.3748/wjg.v16.i17.2158]
Corresponding Author of This Article
Yong Chan Lee, MD, PhD, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, South Korea. leeyc@yuhs.ac
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Brief Article
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World J Gastroenterol. May 7, 2010; 16(17): 2158-2162 Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2158
Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma
Hyung Soon Park, Yu Jin Kim, Woo Ick Yang, Chang Ok Suh, Yong Chan Lee
Hyung Soon Park, Yu Jin Kim, Yong Chan Lee, Department of Internal Medicine, Yonsei University College of Medicine, 120-752 Seoul, South Korea
Woo Ick Yang, Department of Pathology, Yonsei University College of Medicine, 120-752 Seoul, South Korea
Chang Ok Suh, Department of Radiation Oncology, Yonsei University College of Medicine, 120-752 Seoul, South Korea
Author contributions: Park HS analyzed the data and wrote the manuscript; Yang WI performed the histopathological analysis; Suh CO and Lee YC designed the study; Kim YJ and Lee YC edited and reviewed the manuscript.
Correspondence to: Yong Chan Lee, MD, PhD, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, South Korea. leeyc@yuhs.ac
Telephone: +82-2-22281960 Fax: +82-2-3936884
Received: January 17, 2010 Revised: February 10, 2010 Accepted: February 17, 2010 Published online: May 7, 2010
Abstract
AIM: To investigate treatment outcome of Helicobacter pylori (H. pylori)-negative low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
METHODS: In this study, we retrospectively reviewed the clinical outcome and clinicopathologic factors of stage IE H. pylori-negative low-grade gastric MALT lymphoma cases from August 1998 to June 2009.
RESULTS: A total of eleven patients with H. pylori-negative low-grade gastric MALT lymphoma were enrolled in the study and received anti-H. pylori eradication treatment and/or radiotherapy or excisional therapy. Complete remission (CR) of gastric MALT lymphoma was achieved in all patients. The time to CR was 1-66 mo (median, 1 mo).
CONCLUSION: Eradication therapy may be offered as an initial treatment option even in cases of localized H. pylori-negative gastric MALT lymphoma.
