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World J Gastroenterol. Feb 21, 2009; 15(7): 860-864
Published online Feb 21, 2009. doi: 10.3748/wjg.15.860
Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori
Hong Cheng, Fu-Lian Hu
Hong Cheng, Fu-Lian Hu, Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China
Author contributions: Cheng H designed and performed this work; Hu FL directed the design and writing of this work.
Correspondence to: Hong Cheng, Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China. chenghong@medmial.com.cn
Telephone: +86-10-66551122-2581
Fax: +86-10-66518105
Received: December 2, 2008
Revised: January 4, 2009
Accepted: January 11, 2009
Published online: February 21, 2009
Abstract

AIM: To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori (H pylori).

METHODS: Patients who failed in the H pylori eradication therapy for at least one course were randomly allocated into three groups. Group A received rebaprazole 10 mg + amoxicillin 1 g + furazolidone 100 mg, and bismuth subcitrate 220 mg, twice daily for 1 wk; group B received the same regimen of group A but for 2 wk; and group C received the same regimen of group B, but furazolidone was replaced by furazolidone 100 mg three times daily. To record the side effect profiles at the end of the treatment, H pylori eradication was assessed with 13C-urea breath test 4 wk after therapy.

RESULTS: Sixty patients were enrolled including 28 males, and 20 patients in each group. The average age of the patients was 49.2 years, ranging from 18 to 84 years. H pylori eradication rates with per-protocol analysis were 82%, 89% and 90% in the three groups, respectively. Side effects were found in 11 patients, including mild dizziness, nausea, diarrhea and increased bowel movement. None of the 11 patients needed treatment for their side effects.

CONCLUSION: One- or two-week furazolidone and amoxicillin-based quadruple rescue therapy with a low dose furazolidone (100 mg bid) for the eradication of H pylori is effective. Extending the antibiotic course to 14 d could improve the eradication rates.

Keywords: Helicobacter pylori, Rescue therapy, Quadruple therapy, Furazolidone, Low dose