Khalid O, Radaideh S, Cummings OW, O’Brien MJ, Goldblum JR, Rex DK. Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001. World J Gastroenterol 2009; 15(30): 3767-3770 [PMID: 19673017 DOI: 10.3748/wjg.15.3767]
Corresponding Author of This Article
Douglas K Rex, MD, Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, 550 N. University Boulevard UH 4100, Indianapolis, IN 46202, United States. drex@iupui.edu
Article-Type of This Article
Brief Articles
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 14, 2009; 15(30): 3767-3770 Published online Aug 14, 2009. doi: 10.3748/wjg.15.3767
Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001
Omer Khalid, Sofyan Radaideh, Oscar W Cummings, Michael J O’Brien, John R Goldblum, Douglas K Rex
Omer Khalid, Sofyan Radaideh, Department of Medicine, Indiana University Medical Center, Indianapolis, IN 46202, United States
Oscar W Cummings, Department of Pathology, Indiana University Medical Center, Indianapolis, IN 46202, United States
Michael J O’Brien, Department of Anatomic Pathology, Boston University Medical Center, Boston, MA 02118, United States
John R Goldblum, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, United States
Douglas K Rex, Division of Gastroenterology/Hepatology, Indiana University Medical Center, Indianapolis, IN 46202, United States
Author contributions: Khalid O and Radaideh S recorded and collected the data; Rex DK designed the research; Cummings OW, O’Brien MJ and Goldblum JR reviewed slides and reviewed the manuscript; Rex DK analyzed the data; Khalid O and Rex DK wrote the paper.
Correspondence to: Douglas K Rex, MD, Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, 550 N. University Boulevard UH 4100, Indianapolis, IN 46202, United States. drex@iupui.edu
Telephone: +1-317-2788741
Fax: +1-317-2745449
Received: April 7, 2009 Revised: July 16, 2009 Accepted: July 23, 2009 Published online: August 14, 2009
Abstract
AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007.
METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists.
RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement).
CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists.
