Colvin M, Delis A, Bracamonte E, Villar H, Jr LRL. Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol 2009; 15(28): 3560-3564 [PMID: 19630115 DOI: 10.3748/wjg.15.3560]
Corresponding Author of This Article
Luis R Leon Jr, MD, RVT, FACS, Department of Vascular Surgery, Tucson Medical Center, 5301 East Grant Road, Vascular Surgery Section, Tucson, AZ 85712, United States. chrisandluis@yahoo.com
Article-Type of This Article
Case Report
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World J Gastroenterol. Jul 28, 2009; 15(28): 3560-3564 Published online Jul 28, 2009. doi: 10.3748/wjg.15.3560
Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal
Marni Colvin, Aris Delis, Erika Bracamonte, Hugo Villar, Luis R Leon Jr
Marni Colvin, Aris Delis, Hugo Villar, Department of Surgical Oncology, University Medical Center, Tucson, AZ 85724, United States
Erika Bracamonte, Department of Pathology, University Medical Center, Tucson, AZ 85724, United States
Luis R Leon Jr, Department of Vascular Surgery, Tucson Medical Center, Tucson, AZ 85712; Department of Vascular Surgery, University Medical Center, Tucson, AZ 85724, United States
Author contributions: Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr contributed equally to this work; Colvin M, Delis A, Leon LR Jr designed the research; Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr performed the research; Colvin M, Delis A, Leon LR Jr analyzed the data; and Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr wrote the paper.
Correspondence to: Luis R Leon Jr, MD, RVT, FACS, Department of Vascular Surgery, Tucson Medical Center, 5301 East Grant Road, Vascular Surgery Section, Tucson, AZ 85712, United States. chrisandluis@yahoo.com
Telephone: +1-520-3205665
Fax: +1-520-3201377
Received: December 26, 2008 Revised: June 30, 2009 Accepted: July 7, 2009 Published online: July 28, 2009
Abstract
Primary neoplasms arising in the anal canal are relatively unusual. In particular, adenomas and adenocarcinomas are distinctly rare entities in this region. We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy. This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia. Examination revealed a blood-covered pedunculated mass with a long stalk protruding from the anus. The lesion was amputated at the bedside. Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma. This was further evaluated under anesthesia and complete excision of distal anal tissue was performed. Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
