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Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Apr 28, 2009; 15(16): 2016-2019
Published online Apr 28, 2009. doi: 10.3748/wjg.15.2016
High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy
Hong-Jian Wang, Jin-Shui Zhu, Qiang Zhang, Qun Sun, Hua Guo
Hong-Jian Wang, Jin-Shui Zhu, Qiang Zhang, Qun Sun, Hua Guo, Department of Gastroenterology, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Author contributions: Wang HJ wrote the paper; Zhu JS designed the research; Wang HJ and Guo H performed the research; Zhang Q and Sun Q provided new reagent and analytic tools and analyzed data.
Correspondence to: Jin-Shui Zhu, Professor, Department of Gastroenterology, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China. zhujs1803@hotmail.com
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Received: December 16, 2008
Revised: March 2, 2009
Accepted: March 9, 2009
Published online: April 28, 2009
Abstract

AIM: To investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis.

METHODS: Eighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma. Twenty-eight patients had well-differentiated, 22 had moderately differentiated and 30 had poorly differentiated adenocarcinoma. Forty-five patients and 35 patients had lymph node metastasis. Forty-five patients were of Dukes A to B stage, and 35 were of C to D stage. Another 22 paraffin-embedded tissue blocks of normal colorectal epithelium (> 5 cm away from the edge of the tumor) were selected as the control group. All patients with colorectal cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples.

RESULTS: Ezrin expression in colorectal cancer was significantly higher than in normal colorectal mucosa (75.00% vs 9.09%, P < 0.01), and there was a close relationship between ezrin expression and the degree of tumor differentiation, lymph node metastasis and Dukes stage (88.46% vs 50.00%, P < 0.01; 94.28% vs 51.11%, P < 0.01; 94.28% vs 51.11%, P < 0.01).

CONCLUSION: Ezrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process.

Keywords: Colorectal cancer, Ezrin, Malignant tumor, Invasion, Metastasis, Immunohistochemistry