Khabarova Y, Torniainen S, Nurmi H, Järvelä I, Isokoski M, Mattila K. Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia. World J Gastroenterol 2009; 15(15): 1849-1853 [PMID: 19370782 DOI: 10.3748/wjg.15.1849]
Corresponding Author of This Article
Yulia Khabarova, Department of Family Medicine, Northern State Medical University, Troitsky pr.51, Arkhangelsk, 163000, Russia. yuliakaterina@rambler.ru
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World J Gastroenterol. Apr 21, 2009; 15(15): 1849-1853 Published online Apr 21, 2009. doi: 10.3748/wjg.15.1849
Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia
Yulia Khabarova, Suvi Torniainen, Hanna Nurmi, Irma Järvelä, Mauri Isokoski, Kari Mattila
Yulia Khabarova, Department of Family Medicine, Northern State Medical University, Arkhangelsk 163000, Russia
Suvi Torniainen, Hanna Nurmi, Irma Järvelä, Department of Medical Genetics, University of Helsinki, Helsinki 00014, Finland
Mauri Isokoski, Tampere School of Public Health, University of Tampere, Tampere 33014, Finland
Kari Mattila, Medical School, University of Tampere, 33014 and Centre of General Practice, Health District of Pirkanmaa, Tampere 33521, Finland
Author contributions: Khabarova Y designed the research, collected the material, processed the data, and wrote the paper; Torniainen S performed genetic analyses of samples, and wrote the Methods section; Nurmi H provided assistance and technical support for laboratory work and participated in analyses of genotypes; Järvelä I designed the research, supervised the research, and wrote the paper; Isokoski M proposed the study idea, supervised, supported and designed the study, and wrote the paper; Mattila K supervised, supported and designed the study, processed the data, and wrote the paper.
Correspondence to: Yulia Khabarova, Department of Family Medicine, Northern State Medical University, Troitsky pr.51, Arkhangelsk, 163000, Russia. yuliakaterina@rambler.ru
Telephone: +7-8182-655194
Fax: +7-8182-655194
Received: December 26, 2008 Revised: March 14, 2009 Accepted: March 21, 2009 Published online: April 21, 2009
Abstract
AIM: To estimate the prevalence of the lactase non-persistent genotype (C/C-13910) in a northern Russian population in accordance with ethnicity, and to evaluate self-reported milk consumption depending on lactase activity.
METHODS: Blood samples for genotyping lactase activity, defining the C/T-13910 variant by polymerase chain reaction, and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints.
RESULTS: We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%. The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population. The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects, but was not statistically significant.
CONCLUSION: An investigation of the lactase persistent genotype in a northern Russian population has not been performed before. The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population.
