Chen L, Ren GS, Li F, Sun SQ. Expression of Livin and vascular endothelial growth factor in different clinical stages of human esophageal carcinoma. World J Gastroenterol 2008; 14(37): 5749-5754 [PMID: 18837095 DOI: 10.3748/wjg.14.5749]
Corresponding Author of This Article
Guo-Sheng Ren, Department of General Surgery, the First Affiliated Hospital of Chongqing Medical Uni-versity, Chongqing 400016, China. renguosheng726@163.com
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Rapid Communication
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World J Gastroenterol. Oct 7, 2008; 14(37): 5749-5754 Published online Oct 7, 2008. doi: 10.3748/wjg.14.5749
Expression of Livin and vascular endothelial growth factor in different clinical stages of human esophageal carcinoma
Li Chen, Guo-Sheng Ren, Fan Li, Shan-Quan Sun
Li Chen, Department of Thoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Guo-Sheng Ren, Fan Li, Department of General Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Shan-Quan Sun, Anatomy institution of Chongqing Medical University, Chongqing 400016, China
Author contributions: Ren GS and Chen L contributed equally to this work; Chen L and Sun SQ designed research; Chen L and Li F performed research; Chen L contributed new reagents/analytic tools; Li F analyzed data; and Chen L and Ren GS wrote the paper.
Correspondence to: Guo-Sheng Ren, Department of General Surgery, the First Affiliated Hospital of Chongqing Medical Uni-versity, Chongqing 400016, China. renguosheng726@163.com
Telephone: +86-23-89012301 Fax: +86-23-68120808
Received: July 18, 2008 Revised: August 24, 2008 Accepted: August 31, 2008 Published online: October 7, 2008
Abstract
AIM: To investigate the role of Livin and vascular endothelial growth factor (VEGF) in human esophageal carcinoma, and analyze its relationship to clinical stages.
METHODS: Expression of Livin in fresh esophageal cancer tissues was detected by immunohistochemistry (IHC), Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR), and VEGF by Western blotting and RT-PCR. All statistical analyses were performed by SPSS version 11.0.
RESULTS: Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of Livin and VEGF increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of Livin and VEGF was the most significant. Expression of Livin was positively correlated with VEGF.
CONCLUSION: Over-expression of Livin and VEGF contributes to the pathogenesis of esophageal carcinoma.
