Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jun 28, 2008; 14(24): 3792-3797
Published online Jun 28, 2008. doi: 10.3748/wjg.14.3792
Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract
Ammar Natalwala, Robert Spychal, Chris Tselepis
Ammar Natalwala, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom
Robert Spychal, Sandwell and West Birmingham Hopsitals NHS Trust, Birmingham B15 2TT, United Kingdom
Chris Tselepis, CRUK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, United Kingdom
Author contributions: Natalwala A, Spychal R and Tselepis C contributed to the writing, editing and reviewing of the manuscript.
Correspondence to: Dr. Chris Tselepis, CRUK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TH, United Kingdom.
Telephone: +44-121-4142972
Fax: +44-121-6272384
Received: February 5, 2008
Revised: April 25, 2008
Accepted: May 2, 2008
Published online: June 28, 2008

Epithelial-mesenchymal transition (EMT) is a highly conserved process that has been well characterised in embryogenesis. Studies have shown that the aberrant activation of EMT in adult epithelia can promote tumour metastasis by repressing cell adhesion molecules, including epithelial (E)-cadherin. Reduced intracellular adhesion may allow tumour cells to disseminate and spread throughout the body. A number of transcription proteins of the Snail superfamily have been implicated in EMT. These proteins have been shown to be over-expressed in advanced gastrointestinal (GI) tumours including oesophageal adenocarcinomas, colorectal carcinomas, gastric and pancreatic cancers, with a concomitant reduction in the expression of E-cadherin. Regulators of EMT may provide novel clinical targets to detect GI cancers early, so that cancers previously associated with a poor prognosis such as pancreatic cancer can be diagnosed before they become inoperable. Furthermore, pharmacological therapies designed to inhibit these proteins will aim to prevent local and distant tumour invasion.

Keywords: Epithelial-mesenchymal transition, Transcription proteins, E-cadherin, Gastrointestinal cancer