Oral absorption of hyaluronic acid and phospholipids complexes in rats

doi:10.3748/wjg.v13.i6.945

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2007; 13(6): 945-949
Published online Feb 14, 2007. doi: 10.3748/wjg.v13.i6.945

Oral absorption of hyaluronic acid and phospholipids complexes in rats

Si-Ling Huang, Pei-Xue Ling, Tian-Min Zhang

Si-Ling Huang, Pei-Xue Ling, Tian-Min Zhang, Working Station for Postdoctoral Scientific Research, Institute of Biopharmaceuticals of Shandong Province, Jinan 250108, Shandong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the Natural Science Foundation of Shandong Province, China. No. Y2005C31

Correspondence to: Professor Dr. Pei-Xue Ling, Working Station for Postdoctoral Scientific Research, Institute of Biopharmaceuticals of Shandong Province, Jinan 250108, Shandong Province, China. peixue.ling@bausch.com

Telephone: +86-531-88937780-1301 Fax: +86-531-88937780-1822

Received: September 5, 2006
Revised: November 15, 2006
Accepted: December 30, 2006
Published online: February 14, 2007

Abstract

AIM: To prepare a complex of hyaluronic acid (HA) and phospholipids (PL), and study the improvement effect of PL on the oral absorption of HA.

METHODS: The complex of HA-PL (named Haplex) was prepared by film dispersion and sonication method, its physico-chemical properties were identified by infrared spectra and differential scanning calorimetry (DSC). The oral absorption of Haplex was studied. Thirty-two healthy rats were divided into 4 groups randomly: (1) a normal saline (NS) control group; (2) an HA group; (3) a mixture group and (4) a Haplex group. After intragastric administration, the concentration of HA in serum was determined.

RESULTS: The physico-chemical properties of Haplex were different from HA or PL or their mixture. After Haplex was administered to rats orally, the serum concentration of HA was increased when compared with the mixture or HA control groups from 4 h to 10 h (P < 0.05). The ∆AUC_{0-12 h} of Haplex was also greater than that of the other three groups (P < 0.05).

CONCLUSION: The method of film dispersion and sonication can prepare HA and PL complex, and PL can enhance the oral absorption of exogenous HA.

Keywords: Hyaluronic acid, Phospholipids, Complex, Oral absorption, Infrared spectrum, Thermochemistry