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©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 21, 2007; 13(35): 4781-4783
Published online Sep 21, 2007. doi: 10.3748/wjg.v13.i35.4781
Published online Sep 21, 2007. doi: 10.3748/wjg.v13.i35.4781
Gastric adenocarcinoma with features of endodermal sinus tumor
Malvinderjit Singh, Mukul Arya, Sury Anand, Nan Sandar, Department of Gastroenterology, The Brooklyn Hospital Center, Department of Gastroenterology, Wyckoff Heights Medical Center, Brooklyn, NY 11201, United States
Author contributions: All authors contributed equally to the work.
Correspondence to: Malvinderjit Singh, MD, The Brooklyn Hospital Center, Division of Gastroenterology, 121 Dekalb Avenue, Brooklyn, NY 11201, United States. malisingh@hotmail.com
Telephone: +1-718-2506945 Fax: +1-718-2506489
Received: May 19, 2007
Revised: June 1, 2007
Accepted: June 9, 2007
Published online: September 21, 2007
Revised: June 1, 2007
Accepted: June 9, 2007
Published online: September 21, 2007
Abstract
Extragonadal germ cell tumors are rare. The most common sites for EGGCTs are in midline locations such as the mediastinum, retroperitoneum and pineal gland. These tumors rarely present in the stomach. We describe here a case where a middle aged man presented with typical symptoms of gastric cancer. After extensive workup, which included blood work, CT abdomen scan, upper endoscopy, and endoscopic ultrasound, the patient was diagnosed with gastric cancer. However, due to very high blood levels of alpha-fetoprotein, the specimen was sent for special histochemical staining, which demonstrated that the tumor had features of both adenocarcinoma and endodermal sinus tumor. This is a very aggressive tumor with a very poor prognosis.
Keywords: Extragonadal germ cell tumor, Endodermal sinus tumor, Seminoma, Non-seminoma, Adenocarcinoma, Mediastinum, Retroperitoneum, Metastasis, Alpha feto-protein