Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 7, 2006; 12(41): 6577-6584
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6577
Animal models of portal hypertension
Juan G Abraldes, Marcos Pasarín, Juan Carlos García-Pagán
Juan G Abraldes, Marcos Pasarín, Juan Carlos García-Pagán, Hepatic Hemodynamic Laboratory, Liver Unit, ICMDiM, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
Supported by Fondo de Investigación Sanitaria (CM04/00031 and PI050519), Ministerio de Educación y Ciencia, No.SAF 04/04783; Instituto de Salud Carlos III, No. C03/02
Correspondence to: Juan G Abraldes, MD, Liver Unit, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain. jgon@clinic.ub.es
Telephone: +34-93-2279856
Received: July 27, 2006
Revised: August 3, 2006
Accepted: August 11, 2006
Published online: November 7, 2006

Animal models have allowed detailed study of hemodynamic alterations typical of portal hypertension and the molecular mechanisms involved in abnormalities in splanchnic and systemic circulation associated with this syndrome. Models of prehepatic portal hypertension can be used to study alterations in the splanchnic circulation and the pathophysiology of the hyperdynamic circulation. Models of cirrhosis allow study of the alterations in intrahepatic microcirculation that lead to increased resistance to portal flow. This review summarizes the currently available literature on animal models of portal hypertension and analyzes their relative utility. The criteria for choosing a particular model, depending on the specific objectives of the study, are also discussed.

Keywords: Cirrhosis, Nitric oxide, Portal vein