Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 21, 2006; 12(35): 5622-5627
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5622
Assessing risks for gastric cancer: New tools for pathologists
Robert M Genta, Massimo Rugge
Robert M Genta, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Texas, United states
Massimo Rugge, Department of Oncological and Surgical Sciences, University of Padova, Italy
Author contributions: All authors contributed equally to the work.
Correspondence to: Robert M Genta, MD, Pathology and Laboratory Service-113, VA North Texas Health Care System, 4500 S. Lancaster Road, Dallas, TX 75216, United states.
Telephone: +1-214-8570684 Fax: +1-214-8570739
Received: August 3, 2005
Revised: October 20, 2005
Accepted: October 26, 2005
Published online: September 21, 2006

Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians’ approach to the management of patients with gastric conditions.

Keywords: Gastritis, Staging and grading, Gastritis, Histology