Clinical Research
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 28, 2006; 12(32): 5182-5185
Published online Aug 28, 2006. doi: 10.3748/wjg.v12.i32.5182
Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)
Stephanos Karagiannis, Spyros Goulas, Georgios Kosmadakis, Petros Galanis, Dimitrios Arvanitis, John Boletis, Evangelos Georgiou, Christos Mavrogiannis
Stephanos Karagiannis, Spyros Goulas, Petros Galanis, Christos Mavrogiannis, Academic Department of Gastroenterology, Faculty of Nursing, Athens University, General Hospital of Athens “Helena Venizelou”, Greece
Georgios Kosmadakis, John Boletis, Department of Nephrology and Transplantation Center, Laiko General Hospital, Athens, Greece
Dimitrios Arvanitis, Department of Nephrology, A. Fleming General Hospital, Athens, Greece
Evangelos Georgiou, Medical Physics Department, Medical School, Athens University, Greece
Author contributions: All authors contributed equally to the work.
Correspondence to: S. Karagiannis, MD, Nestoros 21A, Neo Iraklio Attikis, 141.21 Athens, Greece.
Telephone: +30-210-6427379 Fax: +30-210-6400500
Received: April 14, 2006
Revised: May 18, 2006
Accepted: May 25, 2006
Published online: August 28, 2006

AIM: To investigate the role of wireless capsule endoscopy (WCE) in detection of small bowel (SB) pathology in patients with chronic renal failure (CRF) and obscure bleeding.

METHODS: Consecutive CRF patients with obscure bleeding were prospectively studied. Patients with normal renal function and obscure bleeding, investigated during the same period with WCE, were used for the interpretation of results.

RESULTS: Seventeen CRF patients (11 overt, 6 occult bleeding) and 51 patients (33 overt, 18 occult bleeding) with normal renal function were enrolled in this study. Positive SB findings were detected in 70.6% of CRF patients and in 41.2% of non-CRF patients (P < 0.05). SB angiodysplasia was identified in 47% of CRF patients and in 17.6% of non-CRF patients. Univariate logistic regression revealed CRF as a significant predictive factor for angiodysplasia (P < 0.05). Therapeutic measures were undertaken in 66% of the patients with the positive findings.

CONCLUSION: According to our preliminary results, SB angiodysplasia was found in an increased prevalence among CRF patients with obscure bleeding. WCE is useful in diagnosis of gastrointestinal pathologies and in planning appropriate therapeutic intervention and, therefore, should be included in the work-up of this group of patients.

Keywords: Chronic renal failure, Obscure gastrointestinal bleeding, Wireless capsule endoscopy, Angiodysplasia