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World J Gastroenterol. Jul 14, 2006; 12(26): 4214-4218
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4214
Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo
Jian Wang, Satoru Murata, Tatsuo Kumazaki
Jian Wang, Department of Interventional Radiology and Vascular Surgery, The First Hospital of Peking University, 100034, Beijing, China
Satoru Murata, Tatsuo Kumazaki, Department of Radiology, Nippon Medical School, Tokyo, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Jian Wang, Department of Interventional Radiology and Vascular Surgery, the First Hospital of Peking University, 100034, Beijing, China. vanjian@sohu.com
Telephone: +86-10-66518436 Fax: +86-10-66518436
Received: November 12, 2005
Revised: December 2, 2005
Accepted: December 7, 2005
Published online: July 14, 2006

AIM: To observe the dynamic changes of liver microcirculation in vivo after arterial embolization with degradable starch microspheres (DSM).

METHODS: DSM were injected into the proper hepatic artery through a silastic tube inserted retrogradely in gastroduodenal artery (GDA) of SD rats. Fluorescent microscopy was used to evaluate the dynamic changes of blood flow through the terminal portal venules (TPVs), sinusoids and terminal hepatic venules (THVs). The movements of DSM debris were also recorded. Six hours after injection of DSM, percentages of THVs with completely stagnant blood flow were recorded.

RESULTS: Two phases of blood flow change were recorded. In phase one: after intra-arterial injection of DSM, slow or stagnant blood flow was immediately recorded in TPVs, sinusoids and THVs. This change was reversible, and blood flow resumed completely. In phase two: after phase one, blood flow in TPVs changed again and three patterns of blood flow were recorded. Six hours after DSM injection, 36.9% ± 9.2% of THVs were found with completely stagnant blood flow.

CONCLUSION: DSM can stop the microcirculatory blood flow in some areas of liver parenchyma. Liver parenchyma supplied by arteries with larger A-P shunt is considered at a higher risk of total microcirculatory blood stagnation after injection of DSM through hepatic artery.

Keywords: Degradable starch microsphere, Hepatic microcirculation, Hepatic arteries, Fluorescence, Transarterial chemoembolization