Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma

doi:10.3748/wjg.v12.i24.3929

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 24

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2505)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

296

HTML

1974

Figures (1-1)

135

Tables (1-2)

100

Sum=2505

Jun 28, 2006 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (10)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Rapid Communication

World J Gastroenterol. Jun 28, 2006; 12(24): 3929-3932
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3929

Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma

Wei Liu, Zai-Cheng Yu, Wen-Feng Cao, Fang Ding, Zhi-Hua Liu

Wei Liu, Zai-Cheng Yu, Department of Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China

Wen-Feng Cao, Fang Ding, Zhi-Hua Liu, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China

Author contributions: All authors contributed equally to the work.

Supported by National Key Program on Basic Research, No. 2004CB518604

Correspondence to: Professor Zai-Cheng Yu, Department of Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China. yuzaicheng@vip.sina.com

Telephone: +86-551-2922241

Received: February 27, 2006
Revised: March 6, 2006
Accepted: March 10, 2006
Published online: June 28, 2006

Abstract

AIM: To investigate the role of transglutaminase 3 (TGM3) gene in human esophageal squamous cell carcinoma (ESCC), and analyze its relationship with clinicopathological parameters.

METHODS: Gene expression of TGM3 in fresh esophageal cancer tissues and their corresponding normal mucosas was detected immunohistochemically(IHC) by means of tissue microarray(TMA). Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 10.0.

RESULTS: Expression rate of TGM3 was reduced to 81.8% in ESCC. Expression of TGM3 was significantly inversely correlated with histological grade of esophageal carcinoma (in grade I, II and III tumors, the reduced expression was 4/7, 57/71, and 20/21, respectively, P < 0.05), whereas it had no obvious correlations with lymph node metastasis and depth of invasion.

CONCLUSION: Reduced expression of TGM3 may play an important role in esophageal carcinogenesis.

Keywords: Esophageal squamous cell carcinoma, Immunohistochemically, Tissue microarray