Zhang L, Shen L, Ma JL, Pan KF, Liu WD, Li J, Xiao SD, Lin SR, Classen M, You WC. Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy. World J Gastroenterol 2006; 12(24): 3915-3918 [PMID: 16804982 DOI: 10.3748/wjg.v12.i24.3915]
Corresponding Author of This Article
Wei-Cheng You, Department of Cancer Epidemiology, Peking University School of Oncology and Beijing Cancer Hospital and Institute, 52 Fu-cheng Road, Hai-dian District, Beijing 100036, China. weichengyou@yahoo.com
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World J Gastroenterol. Jun 28, 2006; 12(24): 3915-3918 Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3915
Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy
Lian Zhang, Lin Shen, Jun-Ling Ma, Kai-Feng Pan, Wei-Dong Liu, Jie Li, Shu-Dong Xiao, San-Ren Lin, Meinhard Classen, Wei-Cheng You
Lian Zhang, Jun-Ling Ma, Kai-Feng Pan, Wei-Cheng You, Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100036, China
Lin Shen, Jie Li, Department of Internal Medicine, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100036, China
Wei-Dong Liu, Linqu Public Health Bureau, Linqu, Shandong 262600, China
Shu-Dong Xiao, Shanghai Institute for Digestive Disease, Shanghai, China
San-Ren Lin, The Third Hospital of Peking University, Beijing, China
Supported by a grant from International Digestive Cancer Alliance and Peking University School of Oncology
Correspondence to: Wei-Cheng You, Department of Cancer Epidemiology, Peking University School of Oncology and Beijing Cancer Hospital and Institute, 52 Fu-cheng Road, Hai-dian District, Beijing 100036, China. weichengyou@yahoo.com
Received: February 8, 2006 Revised: March 5, 2006 Accepted: March 13, 2006 Published online: June 28, 2006
Abstract
AIM: To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China.
METHODS: A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups: 239 patients received one-day quadruple therapy (amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily) and 157 patients received 7-d standard triple therapy (amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid). All the patients underwent a 13C-UBT to assess the eradication of H pylori infection six weeks after treatment.
RESULTS: Two hundred and twenty-nine patients completed the one-day therapy (95.8%) and 148 patients completed the 7-d therapy (94.2%). The one-day therapy eradicated H pylori infection in 64 patients (27.95%). In contrast, 103 patients (69.59%) were H pylori negative after the 7-d therapy (P < 0.01).
CONCLUSION: This pilot study suggests there is no beneficial effect of the one-day therapy in treatment of H pylori infection compared with the 7-d standard therapy.
