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World J Gastroenterol. Jan 14, 2006; 12(2): 327-330
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.327
Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: A three year prospective study
Stojanka Gašparović, Nadan Rustemović, Milorad Opačić, Marina Premužić, Anđelko Korušić, Jadranka Božikov, Tamara Bates
Stojanka Gašparović, Anđelko Korušić, Department of Anesthesiology, Dubrava University Hospital, Zagreb, Croatia
Nadan Rustemović, Milorad Opačić, Marina Premužić, Department of Gastroenterology, Zagreb University Hospital Center, Zagreb, Croatia
Jadranka Božikov, ”Andrija Štampar” School of Public Health, Zagreb University School of Medicine, Zagreb, Croatia
Tamara Bates, “Bates” Clinic, Zagreb, Croatia
Co-first-author: Stojanka Gašparović
Co-correspondence: Nadan Rustemović
Supported by “Bates” Clinic, Svetice 15, Zagreb, Croatia, in the form of grant, equipment and drugs
Correspondence to: Dr.Tamara Bates, Poliklinika “Dr. Bates”, Svetice 15, 10000 Zagreb, Croatia. tamara.bates@gmail.com
Telephone: +385-1-2338000 Fax: +3851-2339833
Received: June 13, 2005
Revised: June 28, 2005
Accepted: July 1, 2005
Published online: January 14, 2006

AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.

METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.

RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P <0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P<0.001). A critical decrease in oxygen saturation (<90%) was documented in 27 patients (2.4%).

CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.

Keywords: Endoscopy, Conscious sedation, Propofol, Hemodynamic adverse effects