E-cadherin in gastric cancer

doi:10.3748/wjg.v12.i2.199

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Jan 14, 2006 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2006; 12(2): 199-203
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.199

E-cadherin in gastric cancer

Annie On On Chan

Annie On On Chan, Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China

Correspondence to: Annie On On Chan, MD, PhD, Honorary Clinical Associate Professor, Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. aoochan@hku.hk

Telephone: +852-2855-5414 Fax: +852-2855-5411

Received: June 7, 2005
Revised: June 28, 2005
Accepted: July 11, 2005
Published online: January 14, 2006

Abstract

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.

Keywords: E-cadherin, Gastric cancer