Zhao JB, Frøkjær JB, Drewes AM, Ejskjaer N. Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World J Gastroenterol 2006; 12(18): 2846-2857 [PMID: 16718808 DOI: 10.3748/wjg.v12.i18.2846]
Corresponding Author of This Article
Jingbo Zhao, Center of Excellence in Visceral Biomechanics and Pain, the Research Building room 404, Aalborg Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. aas.jzhao@nja.dk
Article-Type of This Article
Topic Highlight
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Jing-Bo Zhao, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes, Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Søndre Skovvej 15, DK-9000 Aalborg, Denmark & Center for Sensory-Motor Interactions, Department of Health Science, Aalborg University, Fredrik Bajers Vej 7 D-3, DK-9220 Aalborg, Denmark
Niels Ejskjaer, Department of Medicine M (Diabetes & Endocrinology), Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
Supported by the Danish Diabetes Association, the Research Council of North Jutland County, the Toyota Foundation and the SparNord Foundation
Correspondence to: Jingbo Zhao, Center of Excellence in Visceral Biomechanics and Pain, the Research Building room 404, Aalborg Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. aas.jzhao@nja.dk
Telephone: +45-99326907 Fax: +45-99326801
Received: March 25, 2006 Revised: March 28, 2006 Accepted: April 10, 2006 Published online: May 14, 2006
Abstract
Gastrointestinal (GI) sensory-motor abnormalities are common in patients with diabetes mellitus and may involve any part of the GI tract. Abnormalities are frequently sub-clinical, and fortunately only rarely do severe and life-threatening problems occur. The pathogenesis of abnormal upper GI sensory-motor function in diabetes is incompletely understood and is most likely multi-factorial of origin. Diabetic autonomic neuropathy as well as acute suboptimal control of diabetes has been shown to impair GI motor and sensory function. Morphological and biomechanical remodeling of the GI wall develops during the duration of diabetes, and may contribute to motor and sensory dysfunction. In this review sensory and motility disorders of the upper GI tract in diabetes is discussed; and the morphological changes and biomechanical remodeling related to the sensory-motor dysfunction is also addressed.
