Topic Highlight Open Access
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 14, 2006; 12(18): 2839-2845
Published online May 14, 2006. doi: 10.3748/wjg.v12.i18.2839
Evaluation of the biliary tract in patients with functional biliary symptoms
Peter Funch-Jensen, Asbjørn Mohr Drewes, László Madácsy
Peter Funch-Jensen, Surgical Gastroenterological Department L, Aarhus University Hospital, Aarhus, Denmark
Asbjørn Mohr Drewes, Center for Visceral Biomechanics and Pain, Department of Gastroenterology, Aalborg Sygehus and Center of Sensory Motor Interaction (SMI), University of Aalborg, Denmark
László Madácsy, First Department of Internal Medicine and OMCH Endoscopy Unit, Fejér Megyei Szent György Hospital, Székesfehérvár, Hungary
Correspondence to: Peter Funch-Jensen, MD, DMSc, Professor of Surgery, Surgical Gastroenterological Department L, Aarhus Sygehus, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.
Telephone: +45-86209065
Received: March 25, 2006
Revised: March 28, 2006
Accepted: April 10, 2006
Published online: May 14, 2006


The aim of this paper was to describe functional biliary syndromes and methods for evaluation of the biliary tract in these patients. Functional biliary symptoms can be defined as biliary symptoms without demonstrable organic substrate. Two main syndromes exist: Gallbladder dysfunction and sphincter of Oddi dysfunction. The most important investigative tools are cholescintigraphy and endoscopic sphincter of Oddi manometry. In gallbladder dysfunction a scintigraphic gallbladder ejection fraction below 35% can select patients who will benefit from cholecystectomy. Endoscopic sphincter of Oddi manometry is considered the gold standard in sphincter of Oddi dysfunction but recent development in scintigraphic methods is about to change this. Thus, calculation of hilum-to-duodenum transit time and duodenal appearance time on cholescintigraphy have proven useful in these patients. In conclusion, ambient methods can diagnose functional biliary syndromes. However, there are still a number of issues where further knowledge is needed. Probably the next step forward will be in the area of sensory testing and impedance planimetric methods.

Key Words: Functional biliary pain, Scintigraphy, Manometry, Pain, Sphincter of Oddi, Gallbladder


Evaluation of the biliary tract is of importance in physiological, pathophysiological, and clinical settings. Clinical investigations in patients with well-defined, organic diseases such as gallstones, is outside the scope of this review, where focus is directed towards patients with functional biliary symptoms. Investigations aiming at morphological alterations in the biliary tract are thus not discussed in this paper.

The value of different investigative methods is often fluid: Some methods are used to render probable or document a correlation between symptoms and measurable abnormalities. Others are, or later become, real tools in the diagnostic process of patients with functional biliary symptoms. The methods can roughly be subdivided into two subgroups: Motility investigations, and methods for the evaluations of the sensory conditions. Motility comprises direct measurement of the biliary tract as well as intraluminal transport. A further evaluation of wall characteristics, e.g. by means of impedance planimetry, has, so far, only been conducted in animal experiments[1].

The present review will start with a physiologic background section, followed by a description of patients with functional biliary symptoms and evaluation methods in these patients.


The function of the biliary tract is to store, concentrate, and transport bile from the liver into the duodenum. In order to accomplish this function the extrabiliary tract is composed of a ductal system, a gallbladder, and a sphincter (Sphincter of Oddi) at the termination of the common bile duct. Previously it was believed that there was an additional sphincteric structure at the junction site of the gallbladder and the cystic duct but studies have failed to prove this supposition. Smooth muscles are present in the gallbladder and in the Sphincter of Oddi (SO). Unlike previous belief, no-or only insignificant-musculature is seen in the ducts. Active contractility is therefore only possible in the gallbladder and the SO. Bile flow into the duodenum occurs after food intake, and late in the interdigestive phase II of the duodenum[2]. The main initiator of biliary secretion-apart from bile production of the liver-is the release of the peptide cholecystokinin (CCK). This peptide relaxes the SO and contracts the gallbladder. The effect of CCK on the SO is brought about by a stimulatory action on inhibitory neurons. This effect overrides a direct stimulatory action of CCK on the SO muscles[3]. In addition to the CCK effect, a reflex relationship exists between the gallbladder and the SO, i.e. pressure increase within the gallbladder leads to relaxation of the SO (Figure 1)[4,5]. This implies that gallbladder contraction, e.g. after food intake, allows bile to run from the gallbladder into the ductal system, and further into the duodenum through the relaxed SO. Conversely, when the gallbladder is empty, the gallbladder pressure is low, and the SO actively contracts, thus allowing bile to divert into the gallbladder. A similar reflex relation is seen between the common bile duct and the SO[6]. This is important in post-cholecystectomy patients.

Figure 1
Figure 1 Sphincter of Oddi manometry in a dog during gallbladder distension (upper tracing), and gallbladder emptying (lower tracing). Distension of the gallbladder-mimicking gallbladder contraction -leads to relaxation of the sphincter of Oddi thus permitting free flow of bile into the duodenum. (After reference 5 with permission).

The gallbladder receives nerve fibres from the sympathetic and the parasympathetic systems. In addition there are a number of neurones containing peptides, e.g. CCK, vasoactive intestinal polypeptide (VIP), nitric oxide (NO), and motilin. The sympathetic nerves arise at the Th8-9 level and are relayed in the celiac plexus, with second order fibres travelling along the vascular system to the gallbladder. The parasympathetic innervation arises from both the anterior and posterior vagal trunks and reaches the gallbladder in a similar way as the sympathetic fibres, with the exception that branches from the anterior vagal nerve do not pass through the celiac plexus. Vagal activity stimulates gallbladder contraction directly, and enhances the contractile effect of CCK on the gallbladder. Sympathetic activity has the opposite effect on gallbladder motility. The sympathetic system also transmits sensory inputs to the central nervous system leading to pain. Pain is enhanced by inflammation. The ductal system and the sphincter of Oddi (SO) are innervated in a similar way as the gallbladder, with the highest neural density in the SO.


Biliary pain is mainly characterized according to the symptomatic presentation of gallstone attacks. As in many other gastrointestinal disorders this is not simple, as a variation in symptomatic presentations can be seen in some patients[7]. Nevertheless, according to the existing literature, and the experience of experts, functional biliary pain was defined as absence of demonstrable organic substrate, and[8]: Episodes of severe steady pain located in the epigastrium and right upper quadrant. A number of additional criteria are outlined. One of these is that the pain attack should last at least 30 min. This seems substantiated in patients where the symptoms are derived from the gallbladder. However, if symptoms originate in the SO, this criterion will still await validation. Two types of functional biliary pain syndromes have been described: Gallbladder dysfunction and sphincter of Oddi dysfunction (SOD). The symptomatic presentation seems rather similar, but obviously patients with gallbladder dysfunction still have the gallbladder in situ, whereas SOD dysfunction most often-albeit not unequivocally-is seen in post-cholecystectomy patients.

Gallbladder dysfunction

Gallbladder dysfunction denominates a condition where the gallbladder empties insufficiently in a patient with biliary symptoms, without demonstrable organic substrate, such as gallstones. The prevalence of biliary-type pain without gallstones was found to be 2.4%[9]. Other population studies have found prevalences as high as 7.6% in men[10] and 20.3% in women[11]. Per definition patients with gallbladder dysfunction have impaired gallbladder emptying. Later in this paper the methodology is described. The mechanism of pain is rather obscure: Generally it is believed that some kind of functional obstruction at the transition zone between the gallbladder and the cystic duct exists, leading to gallbladder pressure increase. Possibly, a combination with inflammation amplifies sensory firing. Primary hypersensitivity can also not be ruled out and central neuroplastic changes may be responsible for visceral hypersensitivity. Nevertheless, in a randomised controlled investigation[12], it was shown that patients with gallbladder dysfunction would benefit from cholecystectomy. A number of other papers have supported this finding[13,14]. However, there are still a number of critical issues to be addressed[15].

Sphincter of Oddi dysfunction

Sphincter of Oddi dysfunction (SOD) denominates patients with biliary-type pain and dysfunction of the Sphincter of Oddi. The condition is most often seen in post-cholecystectomy patients. The prevalence of symptoms suggesting SO dysfunction is about 1.5% after cholecystectomy, being more frequent in women[16]. SO dysfunction can be subdivided into three groups according to clinical presentation, laboratory results, and ERCP findings[17]: (1) Patients with type I SO dysfunction have biliary-like pain, elevated liver function tests documented on two or more occasions, delayed contrast drainage (more than 45 min, (Figure 2), and a common bile duct diameter equal to or greater than 12 mm at ERCP; (2) Type II patients present with biliary-like pain, and only one or two of the above mentioned criteria; (3) Type III patients only have biliary-like pain, and none of the above mentioned criteria. The mechanism of pain is also rather obscure in this group of patients. From a theoretical point of view SO abnormalities could give rise to pain due to impeded flow, ischemia arising from spastic contractions, and hypersensitivity of the papilla or the common bile duct. These mechanisms may solely or in combination explain the genesis of pain[18]. In a prospective randomised study it was shown that pain could be alleviated by endoscopic sphincterotomy[17].

Figure 2
Figure 2 Endoscopic cholangiogram during investigation, and 45 min after contrast injection in a patient with complete contrast retention.
Quantitative hepatobiliary scintigraphy

Quantitative hepatobiliary scintigraphy (QHBS) is a non-invasive scintigraphic method where it is possible not only to assess the patency of the biliary system but also to measure the rate of bile flow (Figure 3). 99mTc-N-2,6-dimethylphenylcarbamoylmethyliminodiacetic acid (99mTc-EHIDA) and numerous of its analogues, such as 2, 6-diisopropyliminodiacetic acid (DISIDA) and 2, 4, 6-trimethyl-3-bromoiminodiacetic acid (mebrofenin) are the tracers most widely used for hepatobiliary imaging. After (iv) injection, these 99mTc agents bind loosely to serum proteins and are then rapidly taken up by the hepatocytes and excreted into the bile. This uptake mechanism is similar to that of bilirubin, and hyperbilirubinaemia therefore has an inhibitory effect. After excretion by the hepatocytes, the bile continues to flow into the bile canaliculi, the bile ducts and the gallbladder, and then empties into the duodenum through the SO.

Figure 3
Figure 3 Hepatobiliary scintigraphy. A: Pictures at different time windows; B: Time activity curves are shown for different regions of interest.

Patients should be fasted for a minimum of 4 h prior to the investigation. The gamma-camera is positioned over the right upper abdomen of the supine patient. After an iv bolus injection of 140-180 MBq 99mTc-IDA derivative, gamma-camera images are acquired on a computer (1 frame/min) for 90-120 min. If needed, analogue images can also be obtained every 10 min for the first hour, with delayed images if required (first image 500 000 counts, and then subsequent images for the same length of time). The analogue pictures should be examined for liver radiotracer uptake, size, shape and homogeneity. Under normal circumstances the liver uptake of 99mTc-IDA compounds is rapid, with little if any tracer in the blood pool by 5 min. In most normal fasting subjects, radioactivity appears in the gallbladder (GB) and in the small bowel by 1 h after its administration. The extent of visualisation of the hepatic ducts is variable but the left duct tends to be more prominent than the right. In patients without extrahepatic bile duct obstruction, the level of radioactivity of the common bile duct (CBD) reaches its maximum before 45 min. Excretion of radioactivity into the duodenum occurs by 60 min in 81% of patients with the GB in situ. In the remaining 19% of patients without bowel activity at 60 min, duodenal visualisation is always present after exogenous CCK administration[19].

Gallbladder phase imaging

The GB contraction after consumption of a meal or administration of an exogenous CCK analogue (CCK octapeptide or caerulein) can also be measured by means of QHBS. These data can be acquired in a separate study between 60 and 90 min after the initial isotope administration. QHBS combined with administration of a meal or an exogenous CCK analogue is a validated and accurate method for the measurement of GB motility, with satisfactory reproducibility of both parametric variables and emptying patterns. The method of measuring GB is to place a region of interest (ROI) over the GB with a ROI over the liver background (adjacent to the GB), then to generate a time-activity curve for the GB and to calculate the GB ejection fraction (EF) via the following formula: EF% = (GBmax-GBmin)/GBmax × 100. The degree of GB emptying is CCK dose-dependent, and therefore the mode of administration has a critical effect on the net GB contraction. The GB EF increases as the dose of CCK is increased from 0.5 to 3.3 ng/kg per minute. Then begins to decrease when larger doses are infused, especially when CCK is given as a rapid iv bolus. A large non-physiological dose produces a low EF in association with abdominal pain, even in normal subjects. It has become clear that the GB EFs obtained depend on the procedure used but a GB EF over 35%[12,20,21] can be regarded as indicative of a normal GB function if it is evoked by a total infusion dose of 10 ng/kg CCK, administered during 3-10 min.

Scintigraphic features of gallbladder dysfunction

In clinical practice, the distinctive feature of a GB dysfunction is impaired GB emptying. A GB EF under 35% is a sensitive test for the identification of patients with chronic cholecystitis or GB dysfunction[12,20,21]. However, there is a considerable overlap in EF values[15]. Many of the patients experience a reproduction of biliary pain during CCK infusion. Administration of nitro-glycerine before CCK infusion can abolish biliary pain and normalise the GBEF in a subset of patients with gallbladder dysfunction.

Scintigraphic features of sphincter of Oddi dysfunction

The scintigraphic signs in SOD depend upon the presence or absence of a GB in situ, albeit the latter is rare. In patients with SOD and GB in situ, an intact GB serves as a low-pressure reservoir by compensating the increased bile flow that is diverted into it by the tight and hypertonic SO. Therefore, the CBD does not dilate and the rate of emptying of the isotope from the CBD is usually in the normal range. After CCK administration to patients with a functional SOD, the SO relaxes (except in SOD patients with a paradoxical response to CCK, which is a relatively rare phenomenon) and, if the GB function is intact, the GB EF remains normal. In cholecystectomized subjects with a normal liver function, the flow of the bile from the liver to the duodenum is mainly regulated by the motor activity of the SO. HIDA compounds, which are taken up and secreted by the liver into the bile, can therefore be used as markers to measure the rate of bile flow and indirectly to assess the patency of the SO. In asymptomatic cholecystectomized patients with a normal SO function, HIDA excretion and transit from the liver into the duodenum is rapid, and the time-activity curves are exponential, exhibiting only minor patient-to-patient variations[19]. In cholecystectomized patients with SOD however, cholescintigraphy reveals a prominent bile stasis within the intra- and extrahepatic bile ducts, and a marked delay in the transpapillary isotope transit[22-24]. Retention of a 99mTc-IDA tracer after 120 min in the visually prominent bile ducts on static images of the planar HBS was noted to be a good predictor of an abnormal biliary drainage. Quantitative cholescintigraphic parameters may afford valuable numerical information on the bile flow impairment in the presence of a SOD, thereby increasing the sensitivity (Figure 4). Unfortunately, it is not clear, which scintigraphic variable is optimal to express SOD. We recently compared the sensitivities of these parameters in cholecystectomized patients with SOD diagnosed by manometry, which showed that HDTT was the best predictor of SOD, followed by DAT, and then the T1/2 parameters of the hepatic hilum and CBD Madacsy). The quantitative parameters of the CBD seem to be relatively insensitive, which is probably due to the disturbing influence of other factors, such as the CBD diameter and the duodenal motility phase during the study. In fact, we found that the SO basal pressure relative to the CBD pressure exhibited the best correlation with the QHBS parameters. CCK administration increases the hepatic bile secretion and relaxes the SO; it therefore washes out the bile stasis from the ducts if there is no anatomic obstruction. A differentiation between a fixed anatomic obstruction (organic SO stenosis, bile duct stricture or stones, etc.) and a functional obstruction (SO spasm) can also be made by amyl nitrate or nitro-glycerine administration during QHBS. In order to measure SO relaxation after the administration of a smooth muscle relaxant in patients with SOD, after the baseline evaluation of the QHBS parameters, at 60 min amyl nitrate was administered and the T1/2 parameter of the CBD was recalculated. A reversible biliary obstruction on the QHBS (an obstructive pattern relieved after amyl nitrate) indicates a functional SOD, i.e. an SO spasm, whereas a persistent accumulation of the isotope in the biliary tree (during the baseline condition and after amyl nitrate) suggests a fixed organic obstruction[25]. A differentiation between stenosis and dyskinesia of the SO may be important from a clinical point of view, and it might modify the therapeutic strategy, since endoscopic sphincterotomy is of great benefit in patients with a persistently elevated basal SO pressure and SO stenosis. To summarise, QHBS may be regarded as a useful method for study of the bile flow dynamics in patients with postcholecystectomy syndrome and suspected SOD. QHBS may be applied not only as a simple and non-invasive screening test before SO manometry but also as a reliable diagnostic method during the evaluation and follow-up of patients with suspected SOD.

Figure 4
Figure 4 Hepatobiliary scintigraphic activity curves of regions of interest in sphincter of Oddi dysfunction.

US has become a widely used method for visualisation of the abdominal organs. As it is a non-invasive method without radiation exposure, it has also become a popular method for the investigation of motility disorders of the GB and the SO. US methods are relatively cheap and widely available and they also afford excellent reproducibility and sensitivity. However, their diagnostic accuracy is appreciably investigator-dependent and also influenced by the different forms of methodology.

Ultrasonographic measurement of GB contraction

The GB contraction induced by exogenous CCK or CCK analogue (caerulein) administration can be measured by means of either US or QHBS, but methods involving QHBS are currently regarded as the gold standard. QHBS offers the advantage over US of allowing simultaneous visualisation of the bile ducts, together with non-geometrical measurement of the GB contraction. However, the lack of radiation exposure is a favourable feature of the US methods, because it can be repeated several times in the same patient, which is extremely important in motility studies if normal physiology is investigated. US is also able to determine the approximate volume of the GB, which may be of some importance in the pathophysiology of GB motility. Different formulae are known for calculation of the GB volume. The most widely used is the sum of cylinders method, or Dodd’s formula. With this method, the GB volume (GBV) can be calculated if one multiplies the three axes together and then by Pi/6[26]. The GB EF is calculated from the fasting and post-stimulation GBVs via the well-known formula: GBEF (%) = GBVmax - GBVmin/GBVmax. The refilling of the GB is another characteristic feature of GB motility, which can be calculated as a percentage of the ratio between the GBV in the most contracted state and at the maximum after refilling. The two main types of stimuli, which can be used to evoke GB contraction, are food intake and administration of CCK or a CCK analogue.

Ultrasonographic bile duct imaging

Bile duct imaging with US is more difficult than visualisation of the GB. Most investigators use the right anterior oblique view to visualise the common hepatic duct within the porta hepatis, where the surrounding liver parenchyma gives a good acoustic window. Visualisation of the pancreatic duct in the body of the pancreas may be problematic in a number of patients, because the presence of gas in the stomach and in the intestines above it means that an acoustic window is not available. Moreover, exact determination of the pancreatic duct diameter necessitates its measurement in two different part of the pancreas. The upper limit of normal diameter of the common hepatic duct (also termed hepatocholedochus, because it is not possible to differentiate between common hepatic duct and CBD by US) is less than 8-10 mm, and of the pancreatic duct is less than 2-3 mm.

Ultrasonographic assessment of sphincter of Oddi dysfunction

Ultrasonography has been reported as a method for diagnosing SO dysfunction. The authors measured the bile duct diameter before and after CCK infusion or ingestion of a fatty meal[27,28]. However, these methods have not gained acceptance, probably because of low reproducibility.

Sphincter of Oddi manometry

SO manometry can be done during endoscopic retrograde cholangio-pancreatographic (ERCP) investigation. A triple lumen catheter with sideholes spaced 2 mm apart is introduced into the common bile duct, and then withdrawn until positioned in the SO segment. The catheter is slowly perfused from a hydraulic capillary infusion pump, and external transducers are connected with a computer for direct reading of the manometric tracing. Additionally the readings are stored for later analysis[29,30]. The SO is a high-pressure zone with an elevated baseline and superimposed phasic contractions. The readings may suffer from periodic superimposed artefact patterns. Usually these are easily recognised, but simultaneous endoscopic videorecording may be helpful in separating SO activity from artefact phenomenon (Figure 5)[31]. The parameters measured are baseline pressure and phasic wave amplitude, duration, frequency, and propagation mode. Baseline pressure is measured with the duodenal pressure as zero reference. The amplitude is measured with baseline pressure as zero reference. When evaluating the propagation modality, proximal and distal readings are compared.

Figure 5
Figure 5 Combined video- and manometric recording in the sphincter of Oddi during endoscopy.
Normal SO manometry

In healthy subjects the baseline pressure is around 5-15 mmHg, phasic wave amplitude 100-140 mmHg, wave duration 4-6 s, and frequency 3-6 waves per minute. Most contractions are coordinated, and the direction of contractions is mostly antegrade, with only 5%-20% being retrograde[32]. After cholecystectomy no significant alterations are seen in patients who no longer have symptoms[33,34].

Abnormal SO manometry

SO manometric abnormalities comprise elevated baseline pressure, increased phasic wave amplitude, frequency, and disordered propagation mode (Figure 6, Figure 7). It has been suggested to define SO abnormality as a baseline pressure of more than 40 mmHg, phasic amplitude above 350 mmHg, frequency of more than 7 waves per minute; and a pattern of more than 50% retrograde waves[8]. The clinical importance of these abnormalities is not clear, except for elevated baseline pressure, where it was shown in a randomised study that patients with this abnormality improved clinically after endoscopic sphincterotomy[17].

Figure 6
Figure 6 Endoscopic sphincter of Oddi manometry in a patient with elevated baseline pressure.
Figure 7
Figure 7 Endoscopic sphincter of Oddi manometry. A: Normal antegrade contractions; B: Abnormal retrograde waves.
Pain studies

The fact that there are still “holes” in our understanding of patients with functional biliary pain has led investigators to focus on sensory mechanisms. Clinically, it has been observed that some patients develop pain upon manipulation with the papilla (tender papilla), or during intraductal contrast injection. A further step forward was taken with the demonstration of duodenal-specific visceral hyperalgesia in post-cholecystectomy patients with persistent abdominal pain[35]. Stawowy et al[36-38] has investigated the referred pain area in patients with uncomplicated gallstones and acute cholecystitis before and after cholecystectomy. Although hypersensitivity was found in both groups of patients, the hypothesized prolonged neuroplastic changes, as a possible explanation of post-cholecystectomy syndrome could not be proven. However, in the future it will be of importance to conduct studies in patients with post-cholecystectomy syndrome and also in patients with suspected gallbladder dysfunction.


S- Editor Pan BR E- Editor Bai SH

1.  Duch BU, Andersen H, Gregersen H. Mechanical properties of the porcine bile duct wall. Biomed Eng Online. 2004;3:23.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 18]  [Cited by in F6Publishing: 16]  [Article Influence: 1.0]  [Reference Citation Analysis (0)]
2.  Peeters TL, Vantrappen G, Janssens J. Bile acid output and the interdigestive migrating motor complex in normals and in cholecystectomy patients. Gastroenterology. 1980;79:678-681.  [PubMed]  [DOI]  [Cited in This Article: ]
3.  Behar J, Biancani P. Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action. J Clin Invest. 1980;66:1231-1239.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 123]  [Cited by in F6Publishing: 119]  [Article Influence: 3.0]  [Reference Citation Analysis (0)]
4.  Thune A, Thornell E, Svanvik J. Reflex regulation of flow resistance in the feline sphincter of Oddi by hydrostatic pressure in the biliary tract. Gastroenterology. 1986;91:1364-1369.  [PubMed]  [DOI]  [Cited in This Article: ]
5.  Funch-Jensen P, Sørensen SS. Influence of graded distension of the gallbladder on sphincter of Oddi activity in dogs. Dig Dis. 1991;9:408-413.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 4]  [Cited by in F6Publishing: 4]  [Article Influence: 0.1]  [Reference Citation Analysis (0)]
6.  Rolny P, Funch-Jensen P, Kruse A, Thommesen P. Effect of cholecystectomy on the relationship between hydrostatic common bile duct pressure and sphincter of Oddi motility. Endoscopy. 1991;23:111-113.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 20]  [Cited by in F6Publishing: 20]  [Article Influence: 0.6]  [Reference Citation Analysis (0)]
7.  Berhane T, Vetrhus M, Hausken T, Olafsson S, Søndenaa K. Pain attacks in non-complicated and complicated gallstone disease have a characteristic pattern and are accompanied by dyspepsia in most patients: the results of a prospective study. Scand J Gastroenterol. 2006;41:93-101.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 33]  [Cited by in F6Publishing: 29]  [Article Influence: 2.1]  [Reference Citation Analysis (0)]
8.  Corazziari E, Shaffer EA, Hogan WJ, Sherman S, Toouli J. Functional disorders of the biliary tract and pancreas. Gut. 1999;45 Suppl 2:II48-II54.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 52]  [Cited by in F6Publishing: 56]  [Article Influence: 2.3]  [Reference Citation Analysis (0)]
9.  Barbara L, Sama C, Morselli Labate AM, Taroni F, Rusticali AG, Festi D, Sapio C, Roda E, Banterle C, Puci A. A population study on the prevalence of gallstone disease: the Sirmione Study. Hepatology. 1987;7:913-917.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 343]  [Cited by in F6Publishing: 307]  [Article Influence: 9.8]  [Reference Citation Analysis (0)]
10.  The epidemiology of gallstone disease in Rome, Italy. Part I. Prevalence data in men. The Rome Group for Epidemiology and Prevention of Cholelithiasis (GREPCO). Hepatology. 1988;8:904-906.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 171]  [Cited by in F6Publishing: 112]  [Article Influence: 5.0]  [Reference Citation Analysis (0)]
11.  Prevalence of gallstone disease in an Italian adult female population. Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Am J Epidemiol. 1984;119:796-805.  [PubMed]  [DOI]  [Cited in This Article: ]
12.  Yap L, Wycherley AG, Morphett AD, Toouli J. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology. 1991;101:786-793.  [PubMed]  [DOI]  [Cited in This Article: ]
13.  Westlake PJ, Hershfield NB, Kelly JK, Kloiber R, Lui R, Sutherland LR, Shaffer EA. Chronic right upper quadrant pain without gallstones: does HIDA scan predict outcome after cholecystectomy. Am J Gastroenterol. 1990;85:986-990.  [PubMed]  [DOI]  [Cited in This Article: ]
14.  Chen PF, Nimeri A, Pham QH, Yuh JN, Gusz JR, Chung RS. The clinical diagnosis of chronic acalculous cholecystitis. Surgery. 2001;130:578-81; discussion 581-583.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 45]  [Cited by in F6Publishing: 40]  [Article Influence: 2.1]  [Reference Citation Analysis (0)]
15.  Rastogi A, Slivka A, Moser AJ, Wald A. Controversies concerning pathophysiology and management of acalculous biliary-type abdominal pain. Dig Dis Sci. 2005;50:1391-1401.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 35]  [Cited by in F6Publishing: 29]  [Article Influence: 2.1]  [Reference Citation Analysis (0)]
16.  Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 1993;38:1569-1580.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1479]  [Cited by in F6Publishing: 1332]  [Article Influence: 51.0]  [Reference Citation Analysis (0)]
17.  Geenen JE, Hogan WJ, Dodds WJ, Toouli J, Venu RP. The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with sphincter-of-Oddi dysfunction. N Engl J Med. 1989;320:82-87.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 339]  [Cited by in F6Publishing: 281]  [Article Influence: 10.3]  [Reference Citation Analysis (0)]
18.  Funch-Jensen P. Defining sphincter of oddi dysfunction. Gastrointest Endosc Clin N Am. 1996;6:107-115.  [PubMed]  [DOI]  [Cited in This Article: ]
19.  Madácsy L, Toftdahl DB, Middelfart HV, Hojgaard L, Funch-Jensen P. Comparison of the dynamics of bile emptying by quantitative hepatobiliary scintigraphy before and after cholecystectomy in patients with uncomplicated gallstone disease. Clin Nucl Med. 1999;24:649-654.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 7]  [Cited by in F6Publishing: 7]  [Article Influence: 0.3]  [Reference Citation Analysis (0)]
20.  Adams DB, Tarnasky PR, Hawes RH, Cunningham JT, Brooker C, Brothers TE, Cotton PB. Outcome after laparoscopic cholecystectomy for chronic acalculous cholecystitis. Am Surg. 1998;64:1-5; discussion 5-6.  [PubMed]  [DOI]  [Cited in This Article: ]
21.  Szepes A, Bertalan V, Várkonyi T, Pávics L, Lonovics J, Madácsy L. Diagnosis of gallbladder dyskinesia by quantitative hepatobiliary scintigraphy. Clin Nucl Med. 2005;30:302-307.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 6]  [Cited by in F6Publishing: 6]  [Article Influence: 0.4]  [Reference Citation Analysis (0)]
22.  Corazziari E, Cicala M, Habib FI, Scopinaro F, Fiocca F, Pallotta N, Viscardi A, Vignoni A, Torsoli A. Hepatoduodenal bile transit in cholecystectomized subjects. Relationship with sphincter of Oddi function and diagnostic value. Dig Dis Sci. 1994;39:1985-1993.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 41]  [Cited by in F6Publishing: 35]  [Article Influence: 1.5]  [Reference Citation Analysis (0)]
23.  Shaffer EA, Hershfield NB, Logan K, Kloiber R. Cholescintigraphic detection of functional obstruction of the sphincter of Oddi. Effect of papillotomy. Gastroenterology. 1986;90:728-733.  [PubMed]  [DOI]  [Cited in This Article: ]
24.  Madácsy L, Middelfart HV, Matzen P, Hojgaard L, Funch-Jensen P. Quantitative hepatobiliary scintigraphy and endoscopic sphincter of Oddi manometry in patients with suspected sphincter of Oddi dysfunction: assessment of flow-pressure relationship in the biliary tract. Eur J Gastroenterol Hepatol. 2000;12:777-786.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 21]  [Cited by in F6Publishing: 23]  [Article Influence: 1.0]  [Reference Citation Analysis (0)]
25.  Bertalan V, Madácsy L, Pávics L, Lonovics J. Scintigraphic sign of functional biliary obstruction is pathognomic for sphincter of Oddi dysfunction. Hepatogastroenterology. 2004;51:76-81.  [PubMed]  [DOI]  [Cited in This Article: ]
26.  Dodds WJ, Groh WJ, Darweesh RM, Lawson TL, Kishk SM, Kern MK. Sonographic measurement of gallbladder volume. AJR Am J Roentgenol. 1985;145:1009-1011.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 177]  [Cited by in F6Publishing: 182]  [Article Influence: 4.8]  [Reference Citation Analysis (0)]
27.  Darweesh RM, Dodds WJ, Hogan WJ, Geenen JE, Collier BD, Shaker R, Kishk SM, Stewart ET, Lawson TL, Hassanein EH. Efficacy of quantitative hepatobiliary scintigraphy and fatty-meal sonography for evaluating patients with suspected partial common duct obstruction. Gastroenterology. 1988;94:779-786.  [PubMed]  [DOI]  [Cited in This Article: ]
28.  Simeone JF, Mueller PR, Ferrucci JT Jr, vanSonnenberg E, Hall DA, Wittenberg J, Neff CC, O'Connell RC. Sonography of the bile ducts after a fatty meal: an aid in detection of obstruction. Radiology. 1982;143:211-215.  [PubMed]  [DOI]  [Cited in This Article: ]
29.  Csendes A, Kruse A, Funch-Jensen P, Oster MJ, Ornsholt J, Amdrup E. Pressure measurements in the biliary and pancreatic duct systems in controls and in patients with gallstones, previous cholecystectomy, or common bile duct stones. Gastroenterology. 1979;77:1203-1210.  [PubMed]  [DOI]  [Cited in This Article: ]
30.  Geenen JE, Hogan WJ, Dodds WJ, Stewart ET, Arndorfer RC. Intraluminal pressure recording from the human sphincter of Oddi. Gastroenterology. 1980;78:317-324.  [PubMed]  [DOI]  [Cited in This Article: ]
31.  Madácsy L, Middelfart HV, Matzen P, Funch-Jensen P. Video manometry of the sphincter of Oddi: a new aid for interpreting manometric tracings and excluding manometric artefacts. Endoscopy. 2000;32:20-26.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 3]  [Cited by in F6Publishing: 3]  [Article Influence: 0.1]  [Reference Citation Analysis (0)]
32.  Funch-Jensen P, Kruse A, Ravnsbaek J. Endoscopic sphincter of Oddi manometry in healthy volunteers. Scand J Gastroenterol. 1987;22:243-249.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 23]  [Cited by in F6Publishing: 22]  [Article Influence: 0.7]  [Reference Citation Analysis (0)]
33.  Luman W, Williams AJ, Pryde A, Smith GD, Nixon SJ, Heading RC, Palmer KR. Influence of cholecystectomy on sphincter of Oddi motility. Gut. 1997;41:371-374.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 41]  [Cited by in F6Publishing: 31]  [Article Influence: 1.6]  [Reference Citation Analysis (0)]
34.  Middelfart HV, Matzen P, Funch-Jensen P. Sphincter of Oddi manometry before and after laparoscopic cholecystectomy. Endoscopy. 1999;31:146-151.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 8]  [Cited by in F6Publishing: 6]  [Article Influence: 0.3]  [Reference Citation Analysis (0)]
35.  Desautels SG, Slivka A, Hutson WR, Chun A, Mitrani C, DiLorenzo C, Wald A. Postcholecystectomy pain syndrome: pathophysiology of abdominal pain in sphincter of Oddi type III. Gastroenterology. 1999;116:900-905.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 101]  [Cited by in F6Publishing: 26]  [Article Influence: 4.4]  [Reference Citation Analysis (0)]
36.  Stawowy M, Bluhme C, Arendt-Nielsen L, Drewes AM, Funch-Jensen P. Somatosensory changes in the referred pain area in patients with acute cholecystitis before and after treatment with laparoscopic or open cholecystectomy. Scand J Gastroenterol. 2004;39:988-993.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 24]  [Cited by in F6Publishing: 20]  [Article Influence: 1.8]  [Reference Citation Analysis (0)]
37.  Stawowy M, Funch-Jensen P, Arendt-Nielsen L, Drewes AM. Somatosensory changes in the referred pain area in patients with cholecystolithiasis. Eur J Gastroenterol Hepatol. 2005;17:865-870.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 21]  [Cited by in F6Publishing: 20]  [Article Influence: 1.2]  [Reference Citation Analysis (0)]
38.  Stawowy M, Drewes AM, Arendt-Nielsen L, Funch-Jensen P. Somatosensory changes in the referred pain area before and after cholecystectomy in patients with uncomplicated gallstone disease. Scand J Gastroenterol. 2006;41:833-837.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 19]  [Cited by in F6Publishing: 19]  [Article Influence: 1.2]  [Reference Citation Analysis (0)]