Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 14, 2006; 12(10): 1649-1651
Published online Mar 14, 2006. doi: 10.3748/wjg.v12.i10.1649
Malignant phyllode tumor metastatic to the duodenum
Oktar Asoglu, Hasan Karanlik, Umut Barbaros, Hakan Yanar, Yersu Kapran, Mustafa Kecer, Mesut Parlak
Oktar Asoglu, Hasan Karanlik, Umut Barbaros, Hakan Yanar, Yersu Kapran, Mustafa Kecer, Mesut Parlak, Departments of Surgery, and Pathology, Istanbul Medical School, Istanbul University, Istanbul, Turkey Hasan Karanlik, Department of Surgery, Corlu Millet Hospital, Tekirdag, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Oktar Asoglu, Mesrutiyet M, Elhan S, Meric Konak Ap 50/18, 80220 Nisantasi Istanbul, Turkey.
Telephone: +90-532-4116522
Received: September 13, 2005
Revised: October 3, 2005
Accepted: October 26, 2005
Published online: March 14, 2006

Phyllode tumor (PT) is extremely rare tumor of the breast. Distant metastasis occurs in 10-20% of patients with malignant phyllode tumor. The most common sites of metastases are the lungs and bones. Although theoretically any organ may have metastasis, an isolated duodenum metastasis has not been documented as yet in the English-language literature. We report herein a case with a isolated duodenal metastasis from PT of breast in a 31 year-old-woman who underwent right mastectomy 4 years before because of the recurrent malignant PT. She presented to our hospital with massive upper gastrointestinal bleeding. Clinical evaluation revealed a huge mass originated from duodenum. Urgent laparotomy and pancreaticoduodenectomy were carried out in order to remove the bleeding duodenal mass. The pathologic examination of the resected specimen showed a malignant spindle cell tumor consistent with metastatic malignant PT. Our case of gastrointestinal bleeding due to an isolated duodenal metastasis as a result of hematogenous spread from malignant phyllode tumor of breast is unique in the English literature and pancreaticoduodenectomy is a curative treatment for patients with isolated duodenal involvement.

Keywords: Malignant phyllode tumor, Duodenal metastasis, Pancreaticoduodenectomy