Brief Reports
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2005; 11(7): 1037-1039
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.1037
Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule
A Chowdhury, A Santra, CM Habibullah, AA Khan, J Karunakaramaiah, TSA Kishore, AVR Raju, S Lahiri
A Chowdhury, A Santra, Dept of Gastroenterology, I.P.G.M.E.R, Kolkata, India
CM Habibullah, AA Khan, Center for Liver Disease, DCMS, Hyderabad, India
J Karunakaramaiah, TSA Kishore, AVR Raju, S Lahiri, Biological E.Limited, Hyderabad, India
Author contributions: All authors contributed equally to the work.
Supported by the Biological E Limited, Hyderabad, India
Correspondence to: Dr. S Lahiri, Department of Clinical and Regulatory Affairs, Biological E.Limited, 18/1 and 3 Azamabad, Hyderabad, Zip-500020, India. slahiri@biologicale.com
Telephone: +91-40-27617831 Fax: +91-40-27615309
Received: May 25, 2004
Revised: May 28, 2004
Accepted: June 18, 2004
Published online: February 21, 2005
Abstract

AIM: To establish the safety and efficacy of an indigenously developed r-hepatitis B vaccine using an accelerated schedule and to highlight the social awareness and commitment in preventing the spreading of hepatitis B virus infection.

METHODS: The study was a multicentric, double blind, randomized (3:1) study using three doses of vaccine immunization schedule (20 μg for those above 10 years old and 10 μg for those below 10 years old) on d 0, 30 and 60. One hundred and sixty-six subjects were enrolled (87 males and 76 females aged 5-35 years). The main outcome measure was assessment of immunogenicity and safety.

RESULTS: A 100% seroconversion response was observed on the 30th d after the 1st injection in both the experimental groups. The sero-protection data reported a 41.2-65.6% response on the 30th d after the 1st injection and reached 100% on the 60th d. Descriptive statistical analysis showed a geometric mean titer value of 13.77 mIU/mL in the test (BEVAC) group and 10.95 mIU/mL in the commercial control (ENGERIX-B) group on the 30th d after the 1st injection. The response on the 60th d showed a geometric mean titre value (GMT) of 519.84 mIU/mL in the BEVAC group and 475.46 mIU/mL in the ENGERIX-B group. On the 90th d, the antibody titer response was observed to be 2627.58 mIU/mL in the BEVAC group and 2272.72 mIU/mL in the ENGERIX-B group. Two subjects in each group experienced pains at injection site after the first vaccination. A total of six subjects in both groups experienced a solicited adverse reaction, which included pains, swelling and redness at the injection site, three subjects in the group-B had a pain at the injection site after the third dose. No other serious adverse events occurred and no dose-related local or general symptoms were observed during the study.

CONCLUSION: The vaccine is safe, efficacious and immunogenic in comparison with the well documented ENGERIX-B.

Keywords: Hepatitis B, r-Hepatitis B Vaccines, Immune response, Accelerated vaccination schedule